Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models

Table 1 Values of physical parameters of four curcuminoids examined in this study

Compound	MW^a	logP ^b	MR^c	Source^d
Curcumin	368	2.92	104	S-A
Demethoxycurcumin	338	3.08	98.78	S-A
Bisdemethoxycurcumin	308	3.32	92.10	S-A
Tetrahydrocurcumin	372	2.73	100.63	S-A

^aMolecular weight.
^bHydrophobic parameter expressed as the log of the octanol/water partition coefficient.
^cParameter for steric effects as described using molecular refraction.
^dPurchased from Sigma-Aldrich (St. Louis, MO).

ISSN: 2662-7671