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Table 3 Antinociceptive effect of C. rotundus extract, morphine and diclofenac sodium in formalin-induced paw licking test

From: Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Treatment Dose (mg/kg) Number of licking
Early phase (0-5 min) % inhibition Late phase (15-30 min) % inhibition
Vehicle 0.1 ml/mice 157.00 ± 8.21 - 189.00 ± 6.42 -
Morphine sulphate 5 44.20 ± 5.44* 71.99 8.40 ± 1.81* 95.56
Diclofenac sodium 10 89.60 ± 7.41* 43.22 35.40 ± 2.86* 81.27
HMCR 50 135.20 ± 7.12 14.32 90.80 ± 8.64* 51.96
HMCR 100 89.40 ± 6.88* 43.35 51.40 ± 9.47* 72.80
HMCR 200 60.60 ± 9.32* 61.60 23.80 ± 5.08* 87.41
  1. Each value is presented as the mean ± SEM (n = 5); *p < 0.001 compared with the control group (Dunnett’s test).