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Table 3 Antinociceptive effect of C. rotundus extract, morphine and diclofenac sodium in formalin-induced paw licking test

From: Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Treatment

Dose (mg/kg)

Number of licking

Early phase (0-5 min)

% inhibition

Late phase (15-30 min)

% inhibition

Vehicle

0.1 ml/mice

157.00 ± 8.21

-

189.00 ± 6.42

-

Morphine sulphate

5

44.20 ± 5.44*

71.99

8.40 ± 1.81*

95.56

Diclofenac sodium

10

89.60 ± 7.41*

43.22

35.40 ± 2.86*

81.27

HMCR

50

135.20 ± 7.12

14.32

90.80 ± 8.64*

51.96

HMCR

100

89.40 ± 6.88*

43.35

51.40 ± 9.47*

72.80

HMCR

200

60.60 ± 9.32*

61.60

23.80 ± 5.08*

87.41

  1. Each value is presented as the mean ± SEM (n = 5); *p < 0.001 compared with the control group (Dunnett’s test).