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Table 1 Parasitemia and survival time of infected mice treated with crude extract and solvent fractions of Croton macrostachys in the 4 day suppressive test

From: In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice

Extract

Animal group

Parasitaemia level

% suppression

Survival date

Crude extract

CON

32±0.97

-

7±0.36

CM200

18±1.73

44a3,b3,c3

10±0.33a1,b3,c3

CM400

7±0.31

78a3,b1,c3

14±0.42a3,b3,c3

CM600

3±0.40

91a3

18±0.60a3,c3

CQ25

0.0a3

100

30±0a3

Chloroform fraction

CON

30.43±0.61

-

7.34±0.42

CF200

15.40±0.43

49.4a3,c3

9.00±0.68c3

CF400

10.30±0.58

66.2a3,c3,e3

13.34±1.25a3,c3,e1

CF600

7.34±0.15

75.9a3,c3,d3,e3

16.50±1.08a3,c3,e3

CQ25

0.00±0.00

100.00a3

29.67±0.34a3

Methanol fraction

CON

34.33±1.62

-

6.84±0.17

MF200

21.61±0.54

37.1a3,c3

8.83±1.14c3

MF400

16.30±0.71

52.5a3,c3,e2

8.50±0.56c3

MF600

12.28±0.52

64.2a3,c3,d1,e3

10.00±1.15a1,c3

CQ25

0.00±0.00

100.00a3

30.00±0.00a3

Aqueous fraction

CON

37.47±0.84

-

7.00±0.25

AF200

33.03±0.94

11.8a2,c3

7.84±0.60c3

AF400

26.27±0.69

29.9a3,c3,e3

8.34±0.42c3

AF600

22.94±0.79

38.8a3,c3,d3,e3

9.17±0.31a2,c3

 

CQ25

0.00±0.00

100.00a3

30.00±0.00a3

  1. Data are expressed as mean ± SEM; n = 6; a, compared to control; b, to 600 mg/kg; c, to CQ25mg/kg; d, to 400 mg/kg; e, 200 mg/kg: 1p<0.05, 2p<0.01, 3p<0.001; CF = Chloroform fraction, CQ = chloroquine, MF, methanol fraction, AF, aqueous fraction, CON = Control, CM, crude extract of Croton macrostachys. Numbers refer to dose in mg/kg.