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Table 1 The half maximal inhibition concentration (IC 50 ) of the lipophilic fraction of the marine organism extracts against HIV-1 PR is presented

From: Cytotoxic and HIV-1 enzyme inhibitory activities of Red Sea marine organisms

Phylum

Marine organism

Cytotoxicity IC50(ÎĽg/mL)

SI values

IC50(ÎĽg/mL)

U937

HeLa

Vero

U937

HeLa

HIV-1 PR

Mollusca

B. ampulla

N/Ta

76.53

110.80

N/A

1.4

N/Tb

Rhodophyta

G. filamentosa

N/Ta

N/Ta

N/Ta

N/A

N/A

2.6

Chlorophyta

C. prolifera

52.46

32.32

143.21

2.73

4.43

N/Tb

Phaeophyta

T. turbinatea

N/Ta

N/Ta

N/Ta

N/A

N/A

N/Tb

Tracheophyta

C. rotundata

N/Ta

N/Ta

N/Ta

N/A

N/A

N/Tb

Porifera

H. rubens

N/Ta

N/Ta

N/Ta

N/A

N/A

N/Tb

Porifera

S. officinalis

N/Ta

N/Ta

N/Ta

N/A

N/A

N/Tb

Cnidaria

C. andromeda

N/Ta

N/Ta

N/Ta

N/A

N/A

0.84

Cnidaria

S. heterospiculata

44.54

n/a

43.95

0.99

n/a

8.6

Cnidaria

S. maxima

24.00

30.08

43.95

1.83

1.46

13.1

Cnidaria

S. polydactyla

89.05

20.0

6.80

0.08

0.34

N/Tb

Cnidaria

L. arboreum

6.50

28.10

41.90

6.45

1.46

12.0

Cnidaria

S. trocheliophorum

N/Ta

5.200

10.90

N/A

2.10

N/Tb

Actinomycin Dc

7.8

17.7

11.8

1.5

0.7

N/Tb

Acetylpepstatind

     

5.7

  1. The IC50 values were determined in different cell lines and are presented along with the associated selectivity index (SI) values which represent the relative activity towards the cancer cell lines compared to the Vero cells.
  2. Not tested (N/Ta) samples with inhibitory activities less than 50% at 100 μg/ml.
  3. Not tested (N/Tb) samples with inhibitory activities less than 80% at 100 μg/ml.
  4. Superscript C indicates the anticancer drug used as positive control for the cytotoxicity assay.
  5. Superscript D indicates the positive control used in the PR inhibition assay.