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Table 5 Chemicals derived from herbal medicines not included in this review

From: Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings

Isolated chemicals

Evidence for effects

Phytoestrogens

Hormonal effects in ovarian granulosa cells [107].

Berberine

Comparison with metformin in PCOS [16]; ovarian theca cell hormone production [108].

Catechin derived from Camellia sinensis

Effects of epigallocatechin gallate 1 on cellular metabolic endocrinology [72].

Sapponins derived from Tribulus terrestris

Effects on reproductive endocrinology [109].

Paeoniflorin, glycyrrhizin and glycyrrhetic acid

Ovarian androgen production [110].

Isoflavones isolated from Vitex agnus-castus

Selective oestrogen receptor activity (competitive inhibition via beta oestrogen receptors) [36].