Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model

Table 3 Effect of the extract on some biochemical parameters related to liver and kidney function

	ALT (UI/L)	AST (UI/L)	Protein (mg/mL)	Albumin (mg/dL)	Creatinin (mg/dL)	Potassium (mmol/L)	Sodium (mEq/L)
Water	26.77 ± 3.84	70.96 ± 10.20	23.53 ± 1.51	26.08 ± 2.52	0.38 ± 0.06	6.30 ± 0.79	136.41 ± 5.51
Ethanol	46.44 ± 5.24	116.12 ± 16.69	37.42 ± 5.17^c	33.91 ± 3.41	0.96 ± 0.07^a	9.89 ± 0.93	169.80 ± 7.32
Sucrose	45.42 ± 5.65	130.96 ± 11.65^c	40.66 ± 1.64^b	34.91 ± 3.18	0.90 ± 0.03^a	9.43 ± 0.99	149.80 ± 10.49
EtOH+ Su	52.54 ± 4.79^c	150.32 ± 11.10^a	43.74 ± 4.21^a	33.66 ± 3.88	1.07 ± 0.04^a	10.44 ± 0.71^c	166.01 ± 7.99
EtOH + Su + Nif	22.71 ± 3.15^β	65.16 ± 7.59^α	5.72 ± 1.02^bα	23.24 ± 1.88	0.48 ± 0.05^α	5.10 ± 0.76^α	122.08 ± 10.75^γ
EtOH + Su + Ext50	34.91 ± 6.72	115.48 ± 10.06	16.81 ± 2.52^α	32.29 ± 1.70	0.83 ± 0.06^a	9.26 ± 0.56	139.00 ± 9.49
EtOH + Su + Ext100	27.79 ± 3.28^γ	92.25 ± 12.60^γ	6.73 ± 1.25^bα	28.26 ± 1.67	0.77 ± 0.06^bγ	7.48 ± 0.81^γ	123.03 ± 10.82^γ
EtOH + Su + Ext150	23.05 ± 3.65^β	74.19 ± 12.45^β	6.45 ± 0.67^bα	26.24 ± 1.02	0.52 ± 0.06^α	5.70 ± 0.96^β	117.46 ± 10.80^γ

Each value represents a mean ± S.E.M.; n = 5; ^ap < 0.001; ^bp < 0.01, ^cp < 0.05: significantly different compared to water. ^αp < 0.001, ^βp < 0.01, ^γp < 0.05: significantly different compared to ethanol and sucrose. EtOH + Su = Ethanol and Sucrose; Ext50, Ext100 and Ext150 = Extract at the respective doses of 50, 100 and 150 mg/kg; Nif = Nifedipine (10 mg/kg).

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