Systemic antinociceptive effect of acetone-aqueous extract of from G. bellum (AGB), (panel A) and pure compounds (panel B) in writhing test. Mice (n = 7) were orally administered either with vehicle (VEH), AGB, geraniin, ellagic acid, corilagin, quercetin, acetylsalicylic acid (ASA) or indomethacin 30 min before test. The number of writhes was counted over a 30 min period following the injection of 1% acetic acid. Data are expressed as the percent of the anti-inflammatory effect (A) and the area under curve (AUC) of the number of writning by 25 min. Significantly different from the vehicle group (*P < 0.05 and &P < 0.001) as determined by the analysis of variance followed by Tukey’s test.