Figure 4From: Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury Effects of Pleurotus ostreatus on APAP-CYS adduct formation and GSH depletion. (A) APAP-CYS adduct level in liver tissue homogenate at 0, 1, 2 and 8 hours post APAP or saline pre-treatment in control (white column), APAP treated (black column) and APAP + 10% Pleurotus ostreatus treated (grey column) groups. (B) GSH level in liver tissue homogenate at 0, 1, 2 and 8 hours post APAP or saline pre-treatment in control (white column), APAP treated (black column) and APAP + 10% Pleurotus ostreatus treated (grey column) groups. (C) Serum ALT levels at 0, 1, 2 and 8 hours post APAP or saline pre-treatment in control (white column), APAP treated (black column) and APAP + 10% Pleurotus ostreatus treated (grey column) groups. (Significant = p < 0.05, * significant when compared to the corresponding control group at the same time point, • significant when compared to the corresponding APAP treated group at the same time point. Number of mice = 5/group).Back to article page