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Table 3 Urine profile of acetaminophen metabolites at baseline and 4 weeks

From: An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects

Urine acetaminophen metabolites

Week 0

Week 4

Difference from week 0 to week 4

P Valuea

Acetaminophen glucuronide

 Cmax(mg)

534.34 ± 100.71

553.91 ± 151.27

19.57 ± 124.28

0.661

 Tmax(h)

4.95 ± 1.54

5.26 ± 1.52

0.32 ± 1.67

0.420

 AUC(0–8 hour) (mg. h)

2842.35 ± 654.09

2803.66 ± 655.02

-38.69 ± 342.45

0.675

Acetaminophen sulfate

 Cmax(mg)

109.65 ± 27.66

128.72 ± 48.28

19.08 ± 38.37

0.030

 Tmax(h)

3.37 ± 1.34

4.21 ± 1.47

0.84 ± 1.92

0.072

 AUC(0–8 hour) (mg. h)

541.92 ± 117.29

603.26 ± 197.79

61.34 ± 166.19

0.010

Acetaminophen mercapturate

 Cmax(mg)

12.41 ± 4.81

17.23 ± 8.27

4.82 ± 9.72

0.027

 Tmax(h)

4.84 ± 1.80

4.21 ± 1.62

-0.63 ± 2.50

0.285

 AUC(0–8 hour) (mg. h)

61.56 ± 25.66

84.24 ± 35.78

22.68 ± 44.43

0.024

Unchanged acetaminophen

 Cmax(mg)

18.95 ± 11.01

20.91 ± 7.42

1.96 ± 10.97

0.151

 Tmax(h)

3.05 ± 1.81

3.89 ± 1.94

0.84 ± 2.77

0.202

 AUC(0–8 hour) (mg.h)

84.02 ± 45.36

99.33 ± 31.98

15.31 ± 45.65

0.060

  1. Cmax, Tmax and AUC0-8h of urine acetaminophen metabolites following administration of 1000 mg acetaminophen to participants at week 0 and after 4 weeks of SBR supplementation.
  2. Values are presented as Mean ± SD.
  3. aBetween group comparisons were made using t-test. Statistical comparisons for Cmax and AUC(0-8hour) were conducted using log-transformed data.
  4. Cmax = maximum concentration; Tmax = time of maximum concentration; AUC = area under the urine concentration time curve.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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