Figure 2

Effects of systemic injection of 5-HT antagonists on BVA-induced anti-allodynic action. The behavioral tests for cold allodynia were performed before an intraperitoneal injection of antagonists and after BVA treatment in the four groups of animals: (a) N/S + BV (left, n = 7) and DMSO + BV (right, n = 4), (b) methysergide + BV, and (c) MDL-72222+ BV (n = 7/group). Data are presented as mean ± SEM. **p < 0.01, ***p < 0.001, ns = no significant, by paired t-test.