Antiplasmodial activity of solvent fractions of methanolic root extract of Dodonaea angustifolia in Plasmodium berghei infected mice

Table 4 Effect of the fractions of methanolic root extract of Dodonaea angustifolia on the body weight of the mice

Test substance	Dose (mg/kg)	Body weight (kg)		%change
		D-0	D-4
Butanol	200	30.42 ± 0.68	29.18 ± 0.21	-4.25^c
	400	29.84 ± 0.99	28.66 ± 0.44	-4.11^c
	600	28.70 ± 1.06	27.60 ± 0.34	-3.98^a
Chloroquine	10	29.42 ± 2.17	29.04 ± 1.63	-1.30
Distilled water	1 ml	28.72 ± 0.77	25.74 ± 0.45	-11.58
Chloroform	200	29.74 ± 1.46	27.80 ± 1.92	-6.98
	400	29.50 ± 1.75	27.06 ± 0.83	-9.02
	600	29.56 ± 1.81	27.20 ± 1.10	-8.68
Chloroquine	10	29.38 ± 1.04	29.36 ± 1.32	-0.07
Distilled water	1 ml	30.34 ± 0.92	26.54 ± 1.39	-14.32
Aq. fraction	200	30.26 ± 1.30	28.18 ± 0.64	-7.38
	400	30.98 ± 0.93	28.34 ± 0.42	-9.31
	600	29.40 ± 2.32	27.36 ± 0.46	-7.46
Chloroquine	10	28.84 ± 1.39	28.46 ± 2.24	-1.34
Distilled water	1 ml	31.46 ± 0.83	27.06 ± 0.79	-16.26

a = P < 0.05, c = P < .001, Body weight expressed as mean ± SD, n = 5 the results are expressed as the percent reduction of body weight with reference to day 0. Distilled water = control, D0 = a day infection initiated, D4 = 5^th day of infection.

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