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Table 2 AR, AGEs and COLO 320 inhibitory effects of Compounds 1–9 and kaempferol-3-O-β-D-glucopyranoside compared with Qu, AG and 5-Fu

From: Extracts and compounds with anti-diabetic complications and anti-cancer activity from Castanea mollissina Blume (Chinese chestnut)

Compounds

IC50(μM)

AR

AGEs

COLO 320

1

14.83 ± 0.28

57.06 ± 7.54

>100

2

2.39 ± 0.20***

28.73 ± 2.96

24.10 ± 3.26

3

1.83 ± 0.02***

8.48 ± 1.43*

22.56 ± 4.51

4

1.22 ± 0.06***

5.58 ± 0.48***

3.53 ± 0.42**

5

0.43 ± 0.06***

3.27 ± 0.09***

2.86 ± 0.39**

6

0.63 ± 0.12***

0.75 ± 0.21***

2.43 ± 1.01**

kaempferol-3-O-glc

10.40 ± 0.18**

42.64 ± 3.73

58.84 ± 3.26

7

6.33 ± 1.10**

12.69 ± 5.17

10.07 ± 1.84*

8

0.46 ± 0.01***

4.43 ± 0.36***

5.49 ± 0.23*

9

1.73 ± 0.14***

5.21 ± 0.75***

3.67 ± 0.09**

Qu

12.35 ± 1.06

  

AG

 

10.68 ± 1.06

 

5-Fu

  

8.79 ± 2.57

  1. Data represent mean ± S.E.M. (n=3). IC50 of Compounds< IC50 of Positive Control (Qu, AG, 5-Fu): *** p < 0.01 vs Positive Control, ** p < 0.05 vs Positive Control, * p >0.05 vs Positive Control; IC50 of Compounds> IC50 of Positive Control (Qu, AG, 5-Fu): p > 0.05 vs Positive Control. p > 0.01 vs Positive Control.