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Table 1 Cytotoxic effects of dioscoreanone (DN) on human lung cell lines

From: Growth arrest and apoptosis via caspase activation of dioscoreanone in human non-small-cell lung cancer A549 cells

Cell line Lung cell type Paclitaxel (μM) DN (μM)
GI50 TGI LC50 GI50 TGI LC50
MRC-5 Normal lung fibroblast 0.016 ± 0.005 0.297 ± 0.008 >32 11.4 ± 1.3 19.6 ± 0.7 >32
  3 subtypes of NSCLC       
A549 Adenocarcinoma 0.016 ± 0.001 0.058 ± 0.012 2.800 ± 0.400a 6.2 ± 0.7a 10.3 ± 0.3a 15.7 ± 1.3a
NCI-H226 Squamous cell carcinoma 0.017 ± 0.001 4.898 ± 0.480a 20.672 ± 0.436a 5.7 ± 1.2a 9.8 ± 0.3a 13.6 ± 1.2a
COR-L23 Large cell carcinoma 0.017 ± 0.001 3.450 ± 0.167a 17.725 ± 0.084a 3.7 ± 0.9a 8.0 ± 1.4a 18.9 ± 2.5a
NCI-1688 SCLC 0.012 ± 0.001 20.560 ± 0.147a >32 15.2 ± 2.1 21.1 ± 2.4 >32
  1. DN concentrations required for 50% growth inhibition (GI50), total growth inhibition (TGI), and 50% decrease in cell numbers (LC50) relative to the untreated cells as measured by the SRB assay. Data are presented as the mean ± SD of at least 3 independent experiments.
  2. aStatistical significance (p <0.05) versus MRC-5.