Table 1 Mtb proteasome inhibitory activities of 100 natural products and chemical categories
Categories | Name | IA | Name | IA | Name | IA | Name | IA |
|---|---|---|---|---|---|---|---|---|
Terpenoids | tripterine# | 69.56% | costunolide | 41.75% | ginkgolide | 39.90% | curcumol | 34.66% |
dehydroandrographolide | 32.67% | dehydrocostuslactone | 32.15% | alantolactone | 32.12% | evodine | 31.77% | |
tanshinone | 25.63% | astragaloside A | 23.59% | bilobalide | 18.56% | swertiamain | 14.39% | |
artesunate | 13.83% | betulinol | 6.52% | ginsenoside | 2.62% | limonin | 1.61% | |
glycyrrhetinic Acid | 0.00% | hemslecin A | 0.00% | madecassoside | 0.00% | andrographolide | 0.00% | |
dipsacoside | 0.00% | geniposide | 0.00% | gentiopicroside | 0.00% | tubeimoside A | 0.00% | |
notoginsenoside | 0.00% | asiaticoside | 0.00% | paclitaxel | 0.00% | |||
Flavonoids | pectolinarin# | 88.69% | myricetin# | 84.50% | baicalein# | 84.03% | isoliquiritigenin# | 83.60% |
hispidulin# | 82.06% | baicalin# | 78.47% | quercetin# | 74.40% | icarrin# | 74.34% | |
curcumin# | 69.53% | kaempferol# | 68.29% | alpha mangostin | 64.16% | wogonoside | 59.01% | |
wogonin | 53.97% | nevadensin | 48.01% | genistein | 45.74% | epigallocatechin gallate | 45.21% | |
mangiferin | 31.88% | forsythin | 20.02% | paeoniflorin | 3.05% | tectoridin | 0.00% | |
luteolin | 0.00% | rutin | 0.00% | silmyarin | 0.00% | puerarin | 0.00% | |
apigenin | 0.00% | daidzein | 0.00% | diosmetin | 0.00% | |||
Alkaloids | indirubin | 45.99% | martin hydrochloride | 43.66% | matrine | 23.53% | sophoridine | 11.85% |
sinomenine | 3.77% | bergenin | 3.67% | peimine | 3.05% | berberine | 0.00% | |
lycorine hydrochloride | 0.00% | hanfangchin B | 0.00% | hanfangchin A | 0.00% | camptothecin | 0.00% | |
strychnine | 0.00% | cepharanthine | 0.00% | |||||
Coumarins | imperatorin | 15.90% | scoparone | 0.00% | praeruptorin A | 0.00% | umbelliferone | 0.00% |
coumarin | 0.00% | daphnetin | 0.00% | fraxin | 0.00% | osthole | 0.00% | |
Quinones | emodin# | 73.09% | alkannin | 52.36% | rubimaillin | 46.37% | 1,8-dihydroxyanthraquinone | 36.30% |
aloe-emodin | 34.30% | alizarin | 0.00% | |||||
Phenols | gallogen | 62.50% | salidroside | 34.04% | paeonol | 0.00% | resveratrol | 0.00% |
salicin | 0.00% | |||||||
Organic acid | diffractic acid | 0.00% | syringic acid | 0.00% | shikimicacid | 0.00% | chlorogenic acid | 0.00% |
Lignans | arctigenin | 27.10% | deoxyschizandrin | 23.86% | magnolol | 0.00% | ||
Nucleoside | cordycepin | 7.77% | ||||||
Glycoside | amygdalin | 1.87% | 2,3,5,4′-tetrahydroxy stilbene-2-O-β-D-glucoside | 0.00% | ||||
Stilbenes | polydatin | 0.00% | ||||||
Steroid sapogenin | sarsasapogenin | 0.00% | diosgenin | 0.00% | ||||
Positive control | MG132 | 79.66% |