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Table 1 Mtb proteasome inhibitory activities of 100 natural products and chemical categories

From: Identification of plant-derived natural products as potential inhibitors of the Mycobacterium tuberculosis proteasome

Categories Name IA Name IA Name IA Name IA
Terpenoids tripterine# 69.56% costunolide 41.75% ginkgolide 39.90% curcumol 34.66%
dehydroandrographolide 32.67% dehydrocostuslactone 32.15% alantolactone 32.12% evodine 31.77%
tanshinone 25.63% astragaloside A 23.59% bilobalide 18.56% swertiamain 14.39%
artesunate 13.83% betulinol 6.52% ginsenoside 2.62% limonin 1.61%
glycyrrhetinic Acid 0.00% hemslecin A 0.00% madecassoside 0.00% andrographolide 0.00%
dipsacoside 0.00% geniposide 0.00% gentiopicroside 0.00% tubeimoside A 0.00%
notoginsenoside 0.00% asiaticoside 0.00% paclitaxel 0.00%   
Flavonoids pectolinarin# 88.69% myricetin# 84.50% baicalein# 84.03% isoliquiritigenin# 83.60%
hispidulin# 82.06% baicalin# 78.47% quercetin# 74.40% icarrin# 74.34%
curcumin# 69.53% kaempferol# 68.29% alpha mangostin 64.16% wogonoside 59.01%
wogonin 53.97% nevadensin 48.01% genistein 45.74% epigallocatechin gallate 45.21%
mangiferin 31.88% forsythin 20.02% paeoniflorin 3.05% tectoridin 0.00%
luteolin 0.00% rutin 0.00% silmyarin 0.00% puerarin 0.00%
apigenin 0.00% daidzein 0.00% diosmetin 0.00%   
Alkaloids indirubin 45.99% martin hydrochloride 43.66% matrine 23.53% sophoridine 11.85%
sinomenine 3.77% bergenin 3.67% peimine 3.05% berberine 0.00%
lycorine hydrochloride 0.00% hanfangchin B 0.00% hanfangchin A 0.00% camptothecin 0.00%
strychnine 0.00% cepharanthine 0.00%     
Coumarins imperatorin 15.90% scoparone 0.00% praeruptorin A 0.00% umbelliferone 0.00%
coumarin 0.00% daphnetin 0.00% fraxin 0.00% osthole 0.00%
Quinones emodin# 73.09% alkannin 52.36% rubimaillin 46.37% 1,8-dihydroxyanthraquinone 36.30%
aloe-emodin 34.30% alizarin 0.00%     
Phenols gallogen 62.50% salidroside 34.04% paeonol 0.00% resveratrol 0.00%
salicin 0.00%       
Organic acid diffractic acid 0.00% syringic acid 0.00% shikimicacid 0.00% chlorogenic acid 0.00%
Lignans arctigenin 27.10% deoxyschizandrin 23.86% magnolol 0.00%   
Nucleoside cordycepin 7.77%       
Glycoside amygdalin 1.87% 2,3,5,4′-tetrahydroxy stilbene-2-O-β-D-glucoside 0.00%     
Stilbenes polydatin 0.00%       
Steroid sapogenin sarsasapogenin 0.00% diosgenin 0.00%     
Positive control MG132 79.66%       
  1. IA: inhibitory activity; #natural products with inhibitory activity of Mtb proteasome more than 65%. Different categories of natural products were highlighted using bold texts in the table. The concentration of natural products was 200 μM with the exception of MG132 (100 μM). Data are shown as mean of three independent experiments.