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Table 4 Nutritional supplement-related erythrocyte fatty acid profile changes (expressed as% total fatty acid composition; n = 79)*

From: Echium oil is not protective against weight loss in head and neck cancer patients undergoing curative radio(chemo)therapy: a randomised-controlled trial

Fatty acids W0 W4 % change
     I    C   p    I    C   p    I    C   p
n -3
ALA 0.14 (0.11, 0.20)c 0.13 (0.12, 0.18)b NS 0.17 (0.14, 0.23)c 0.12 (0.09, 0.15)b <0.0001 25.40 (−4.50, 63.60) −16.70 (−33.30, 0.00) <0.0001
EPA 0.66 (0.47, 0.81)c 0.68 (0.57, 0.88) NS 0.75 (0.66, 0.90)c 0.62 (0.50, 0.82) 0.02 14.40 (−2.78, 37.78) −5.30 (−21.80, 8.80) <0.001
n -6
LA 6.72 (5.94, 7.49)d 6.71 (5.88, 7.44)a NS 6.03 (5.25, 6.81)d 6.68 (5.71, 7.16)a NS −8.35 (−15.38, −2.48) −3.80 (−9.60, 3.50) 0.02
GLA 0.04 (0.02, 0.05)b 0.05 (0.03, 0.06)a NS 0.06 (0.04, 0.07)b 0.03 (0.02, 0.06)a <0.01 41.65 (−20.00, 133.3) −20.00 (−50.00, 16.70) <0.001
DGLA 1.21 (1.13, 1.42)d 1.34 (1.21, 1.65) 0.04 1.52 (1.22, 1.78)d 1.36 (1.14, 1.68) NS 18.75 (1.75, 35.30) 2.40 (−6.20, 6.80) <0.0001
AA 12.84 (11.39, 13.35) 12.80 (11.72, 13.50) NS 12.78 (11.77, 13.37) 12.71 (11.71, 13.64) NS 2.35 (−2.05, 7.13) −0.80 (−5.30, 5.00) NS
  1. *Data presented as median (Q1, Q3). Within-group significant differences were indicated by letters a (p < 0.05), b (p < 0.01), c (p < 0.001), d (p < 0.0001). Five patients refused second blood analysis, one was admitted to ICU. Significant P-values provided in bold.