Effect of DHSGT on mRNA expression of leptin, adiponectin, PPAR-γ, and UCP-2 in visceral adipose tissue of HFD-induced obese mice. Expression levels of (A) leptin, (B) adiponectin, (C) PPAR-g, and (D) UCP-2. Values are expressed as means ± SEM (n = 5 animals/group). Significant differences were observed between the Control and HFD groups: ##, p < 0.01; ###, p < 0.001. Significant differences were observed between the HFD and HFD-DHSGT groups, respectively: **, p < 0.01; ***, p < 0.001. DHSGT, Dohaekseunggi-tang; PPAR-γ, peroxisome proliferator activator receptor-γ; UCP-2, mitochondrial uncoupling protein-2, HFD, high-fat diet.