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Table 1 Cardiovascular parameters in two-kidney, one-clip Goldblatt hypertensive rats after 6 weeks of daily oral treatment with captopril (30 mg/kg per day), low-dose DAL (210 mg/kg per day) (DAL-L) and high-dose DAL (420 mgkg/per day) (DAL-H), compared with untreated controls (model) and sham-operated rats (sham)

From: Aqueous extract of dioscorea opposita thunb. normalizes the hypertension in 2K1C hypertensive rats

Parameter

Sham

Model

Captopril

DAL-L

DAL-H

BW (g)

572.21 ± 84.23

586 ± 110.32

456.21 ± 44.46#

546.21 ± 74.12△

552.43 ± 47.87△

HW (g)

1.46 ± 0.17

2.0 ± 0.27*

1.50 ± 0.17#

1.47 ± 0.22#

1.62 ± 0.19*,#,△

LHW (mg)

268.2 ± 0.03

396.2 ± 0.09*

239.3 ± 0.02*,#

300.3 ± 0.04*,#

310.6 ± 0.03*,#,△

HW/BW

2.55 ± 0.45

3.56 ± 0.72*

3.05 ± 0.44*,#

2.9 ± 0.55*,#

2.41 ± 0.38*,#,△

LVAWTh

0.28 ± 0.03#

0.42 ± 0.06*

0.25 ± 0.03#

0.24 ± 0.04*,#

0.23 ± 0.03*,#,△

  1. Abbreviations: BW body weight, HW heart weight, HW/BW heart weight to body weight ratio, LHW left heart weight, LVAWTh left ventricular anterior wall thickness.
  2. Values are mean ± s.e.m.
  3. *P < 0.05 vs. sham; #P < 0.05 vs. model; △P < 0.05 vs. captopril.