Table 1 Effects of sclerotial extracts of L. rhinocerotis cultivar TM02 on carrageenan induced paw edema in rats
Group | Dose (mg/kg body weight) | Paw edema volume (ml) | ||||
|---|---|---|---|---|---|---|
1sthour | 2ndhour | 3rdhour | 4thhour | 5thhour | ||
Control | 0.28 ± 0.02 | 0.76 ± 0.04 | 0.85 ± 0.03 | 0.90 ± 0.04 | 0.86 ± 0.04 | |
CWE TM02 | 25 | 0.25 ± 0.02 (12) | 0.52 ± 0.04* (32) | 0.70 ± 0.03 (18) | 0.70 ± 0.03* (22) | 0.65 ± 0.04* (25) |
50 | 0.18 ± 0.02 (36) | 0.40 ± 0.07* (48) | 0.50 ± 0.06* (42) | 0.51 ± 0.05* (44) | 0.46 ± 0.05* (47) | |
100 | 0.18 ± 0.01 (35) | 0.22 ± 0.04* (71) | 0.33 ± 0.04* (62) | 0.41 ± 0.03* (55) | 0.35 ± 0.02* (60) | |
200 | 0.11 ± 0.03* (61) | 0.13 ± 0.03* (83) | 0.10 ± 0.03* (88) | 0.11 ± 0.03* (88) | 0.10 ± 0.03* (89) | |
HMW | 53** | 0.11 ± 0.02* (63) | 0.12 ± 0.02* (84) | 0.12 ± 0.02* (86) | 0.09 ± 0.02* (90) | 0.08 ± 0.02* (91) |
MMW | 35** | 0.16 ± 0.03* (44) | 0.30 ± 0.04* (61) | 0.35 ± 0.05* (65) | 0.51 ± 0.05* (43) | 0.44 ± 0.03* (49) |
LMW | 112** | 0.23 ± 0.03 (20) | 0.46 ± 0.05* (39) | 0.51 ± 0.05* (41) | 0.51 ± 0.04* (43) | 0.47 ± 0.04* (46) |
ME TM02 | 200 | 0.24 ± 0.05 (15) | 0.68 ± 0.04 (11) | 0.78 ± 0.04 (9.0) | 0.73 ± 0.04* (19) | 0.69 ± 0.03* (20) |
HWE TM02 | 200 | 0.20 ± 0.03 (31) | 0.41 ± 0.06* (46) | 0.50 ± 0.05* (42) | 0.49 ± 0.04* (46) | 0.47 ± 0.03* (45) |
Indomethacin | 10 | 0.18 ± 0.03 (35) | 0.23 ± 0.03* (69) | 0.26 ± 0.03* (69) | 0.37 ± 0.03* (59) | 0.34 ± 0.03*(57) |