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Figure 7 | BMC Complementary and Alternative Medicine

Figure 7

From: Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB

Figure 7

Effect of AMEAE of caspases activation. (A) Relative luminescence dose-dependent activation of caspase-8, -9 and -3/7 in A549 cells treated with various concentrations of AMEAE. Caspase-9 and -3/7 were significantly activated at 10 to 40 μg/mL concentrations. Meanwhile, caspase-8 was activated at higher concentrations (20 and 40 μg/mL). (B) A549 cells were treated with the indicated concentrations of AMEAE for 24 h. The cell lysates were evaluated for levels of cleaved caspase-3 and -9. AMEAE induced the up-regulation of cleaved caspase-3 and -9. (C) The quantitative analysis was expressed as a ratio to the expression of β-actin. The data represent the means ± SEM of three independent experiments. *p < 0.05 compared with the untreated group.

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