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Table 1 Safety evaluation of W-LHIT treatment

From: Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model

Treatment

Dose

Time

Death (12 hrs)

Death (24 hrs)

Morbidity percentage

Mortality percentage

Acute

Water

10X

1 day

0/5

0/5

0

0

W-LHIT

10X

1 day

0/5

0/5

0

0

Chronic

Water

5X

14 days

0/5

0/5

0

0

W-LHIT

5X

14 days

0/5

0/5

0

0

 

BUN (mg/dL)

Alanine aminotransferase (U/L)

White blood cells (10^3/ μL)

Red blood cells (10^6/ μL)

Hemoglobin (g/dL)

Platelets (10^3/ μL)

neutrophils (10^3/ μL)

lymphocytes (10^3/ μL)

eosinophils (10^3/ μL)

Basophils (10^3/ μL)

Water

27.0 ± 2.8

27.5 ± 10.6

6.6 ± 3.1

6.6 ± 3.5

13.7 ± 1.0

1155.0 ± 706.8

2920.5 ± 1247.2

3340.0 ± 2248.2

63.8 ± 82.1

0.0 ± 0.0

W-LHIT

21.0 ± 4.4

33.0 ± 5.4

6.0 ± 3.5

8.1 ± 0.6

12.9 ± 0.8

1056.2 ± 526.3

2233.4 ± 1692.3

3499.2 ± 1763.0

52.0 ± 71.3

0.0 ± 0.0

Reference

14-32

16-58

5.4-16.0

6.7-9.71

10.2-16.6

799-1300

1900-3600

8000-18000

0-500

0-400

  1. No morbidity or mortality was observed in acute and chronic W-LHIT treated or normal control mice. Liver and kidney function test and complete blood test results were all in normal range.