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Table 7 MIC of antibiotics in combination with plant at their MIC/2 and MIC/5 against selected MDR bacteria strains

From: Antibiotic-potentiation activities of four Cameroonian dietary plants against multidrug-resistant Gram-negative bacteria expressing efflux pumps

Antibiotics Plant extracts and MIC
Bacterial strains   Capsicum frutescens Brassica oleacera var. butyris Brassica oleacera var. Italica Basilicum polystachyon
MIC MIC/2 MIC/5 MIC/2 MIC/5 MIC/2 MIC/5 MIC/2 MIC/5
CEF AG100 - - - - - - - - -
EA27 256 - - - - 128 (0.5) s 256 (1)1 256 (1)1 256 (1)1
CM64 - - - - - - - - -
KP55 - - - - - - - - -
KP63 - - - - - - - - -
NAE16 - - - - - - - - -
PA124          
AMP AG100 - - - - - - - - -
EA27 - - - - - - - - -
CM64 - - - - - - - - -
KP55 - - - - - - - - -
KP63 - - - - - - - - -
NAE16 - - - - - - - - -
CIP AG100 32 32 (1)I 64 (2)1 8 (0.25) S 8 (0.25) S 64 (2)1 64 (2)I 64 (2)1 128 (4)1
EA27 16 32 (2)1 32 (2)1 4 (0.25) S 4 (0.25) S 8 (0.5) S 8 (0.5) S 128 (8)A 128 (8)A
CM64 16 16 (1)I 16 (1)I 16 (1)I 16 (1)I 16 (1)I 16 (1)I 64 (4)1 128 (8)A
KP55 16 4 (0.25) S 8 (0.5) S 2 (0.125) S 4 (0.25) S 4 (0.25) S 16 (1)I 8 (0.5) S 8 (0.5) S
KP63 8* 4 (0.5) S 4 (0.5) S 1* (0.125) S 1* (0.125) S 1 (0.125) S 4 (0.25)S 16 (1)I 16 (1)I
NAE16 8* 2 (0.25) S 2 (0.25) S 2* (0.25) S 2* (0.25) S 2 (0.25) S 2 (0.25)S 8* (1)I 8 (1)I
PA124 64 32 (0.5) S 32 (0.5) S 32 (0.5) S 32 (0.5) S 32 (0.5) S 64 (1)1 32 (0.5) S 32 (0.5) S
ERY AG100 32 16 (0.5) S 16 (0.5) S 8 (0.25) S 8 (0.25) S 16 (0.5) S 16 (0.5) S 64 (2)1 64 (2)1
EA27 32 32 (1)I 32 (1)I 64 (2)1 64 (2)1 64 (2)1 64 (2)1 64 (2)1 64 (2)1
CM64 32 64 (2)1 16 (0.5) S 32 (1)I 32 (1)I 32 (1)I 32 (1)I 64 (2)1 64 (2)1
KP55 128 128 (1) I 128 (1) I 64 (0.5) S 64 (0.5) S 64 (0.5) S 128 (1)I 256 (2)1 256 (2)1
KP63 128 32 (0.25) S 64 (0.5) S 32 (0.25) S 64 (0.5) S 64 (0.5) S 64 (0.5) S 256 (2)1 256 (2)1
NAE16 128 16 (0.125) S 16 (0.125) S 32 (0.25) S 64 (0.5) S 128 (1)I 128 (1)I 256 (2)1 256 (2)1
PA124 512 256 (0.5) S 256 (0.5) S 256 0.5) S 256 (0.5) S 256 (0.5)S 256 (0.5) S 128 (0.25) S 256 0.5) S
KAN AG100 32 32 (1)I 64 (2)1 16 (0.5) S 16 (0.5) S 32 (1)I 32 (1)I 32 (1)I 32 (1)I
EA27 32 8 (0.25) S 8 (0.25) S 8 (0.25) S 8 (0.25) S 16 (0.5)S 16 (0.25) S 64 (2)1 64 (2)1
CM64 64 64 (1)I 64 (1)I 16 (0.25) S 32 (0.5) S 32 (0.5)S 32 (0.5) S 32 (0.5) S 32 (0.5) S
KP55 64 16 (0.25) S 16 (0.25) S 16 (0.25) S 16 (0.25) S 16 (0.25)S 16 (0.25) S 16 (0.25) S 16 (0.25) S
  KP63 64 64 (1)I 64 (1)I 16 (0.25) S 16 (0.25) S 16 (0.25) S 32 (0.5) S 32 (0.5) S 32 (0.5) S
  NAE16 64 64 (1)I 64 (1)I 32 (0.5) S 32 (0.5) S 64 (1)I 64 (1)I 64 (1)I 64 (1)I
  PA124 128 128 (1)I 128 (1)I 16 (0.125) S 16 (0.125) S 128 (1)I 128 (1)I 256 (2)1 256 (2)1
TET AG100 32 8 (0.25) S 8 (0.25) S 16 (0.5) S 16 (0.5) S 4 (0.25) S 4 (0.125) S 16 (0.5) S 32 (1)I
  EA27 128 64 (0.5) S 64 (0.5) S 16 (0.125) S 16 (0.125) S 4 (0.031) S 32 (0.25) S 64 (0.5) S 64 (0.5) S
  CM64 64 128 (2)1 128 (2)1 4 (0.062) S 8 (0.125) S 64 (1)I 64 (1)I 128 (2)1 256 (4)1
  KP55 16 2 (0.125) S 4 (0.25) S 1 (0.062) S 1 (0.062) S 2 (0.125) S 2 (0.125) S 16 (1)I 16 (1)I
  KP63 32 8 (0.25) S 8 (0.25) S 8 (0.25) S 16 (0.5) S 16 (0.5) S 8 (0.25) S 16 (0.5) S 16 (0.5) S
  NAE16 128 64 (0.5) S 64 (0.5) S 128 (1)I 128 (1)I 64 (0.5) S 64 (0.5) S - -
  PA124 64 32 (0.5) S 64 (1)I 16 (0.25) S 16 (0.25) S 32 (0.5) S 32 (0.5) S 64 (1)I 64 (1)I
STR AG100 64 256 (4)1 256 (4)1 128 (1)I 128 (1)I 64 (0.5) S 128 (1)I 128 (1)I 128 (1)I
EA27 8 32 (4)1 32 (4)1 4 (0.5)S 8 (1)I 2 (0.25) S 2 (0.5) S 8 (1)I 8 (1)I
CM64 64 256 (4)1 256 (4)1 8 (0.125) S 16 (0.5) S 16 (0.5) S 16 (0.5) S 64 (1)I 64 (1)I
KP55 16 32 (4)1 32 (4)1 16 (1)I 16 (1)I 16 (1)I 16 (1)I 16 (1)I 16 (1)I
KP63 64 256 (4)1 256 (4)1 128 (1)I 128 (1)I 128 (1)I 128 (1)I 128 (1)I 128 (1)I
NAE16 64 256 (4)1 256 (4)1 64 (0.5) S 64 (0.5) S 64 (0.5) S 64 (0.5) S 128 (1)I 128 (1)I
PA124 64 256 (4)1 256 (4)1 32 (0.5) S 32 (0.5) S 32 (0.5) S 32 (0.5) S 64 (1)I 64 (1)I
CHL AG100 16 4 (0.25) S 4 (0.25) S 4 (0.25) S 4 (0.25) S 16 (1)I 16 (1)I 16 (1)I 16 (1)I
EA27 256 - - 64 (0.25) S 128 (0.5) S 32 (0.125) S 64 (0.25) S 256 (1)I 256 (1)I
CM64 128 32 (0.25) S 32 (0.25) S 16 (0.125) S 16 (0.125) S 64 (0.5) S 64 (0.5) S 256 (2)1 256 (2)1
KP55 64 32 (0.5) S 32 (0.5) S 16 (0.25) S 32 (0.5) S 32 (0.5) S 32 (0.5) S 64(1)1 64 (1)1
  KP63 128 128 (1)I 128 (1)I 64 (0.5) S 64 (0.5) S 32 (0.125) S 32 (0.5) S 64 (0.5) S 64 (0.5) S
  NAE16 256 16 (0.062) S 32 (0.125) S 8 (0.031) S 16 (0.062) S 32 (0.125) S 32 (0.125) S 128 (0.5) S 128 (0.5) S
  PA124 512 256 (0.5) S 256 (0.5) S 256 (0.5) S 256 (0.5) S 256 (0.5) S 256 (0.5) S 256 (0.5) S 256 (0.5) S
NOR AG100 16 16 (1)I 16 (1)I 4 (0.25) S 8 (0.5) S 8 (0.5) S 8 (0.5) S 16 (1)I 16 (1)I
EA27 16 128 (4)1 128 (4)1 8 (0.5) S 8 (0.5) S 2 (0.125) S 4 (0.25) S 8 (0.5) S 16 (1)I
CM64 128 256 (2)1 256 (2)1 8 (0.0625) S 16 (0.125) S 128 (1)I 128 (1)I 256 (2)1 256 (2)1
KP55 128 64 (0.5) S 64 (0.5) S 64 (0.5) S 64 (0.5) S 8 (0.0625) S 16 (0.125) S 64 (0.5) S 128 (1)I
KP63 8 32 (4)1 32 (4)1 4 (0.25) S 4 (0.25) S 8 (1)I 8 (1)I 8 (1)I 8 (1)I
  NAE16 32 8 (0.25) S 16 (0.5) S 8 (0.25) S 8 (0.25) S 4 (0.125) S 4 (0.125) S 8 (0.25) S 8 (0.25) S
  PA124 256 128 (0.5) S 128 (0.5) S 128 (0.5) S 128 (0.5) S 128 (0.5) S 128 (0.5) S 256 (1)1 256 (1)1
  1. s: Synergy; I: Indifference; A: Antagonism; ( ): FIC values; -: MIC > 512 μg/mL or not determined FIC; ATB: Antibiotic; CIP: Ciprofloxacin, NOR: Norfloxacin, CHL: Chloramphenicol, STR: Streptomycin, TET: Tetracycline, KAN: Kanamycin, ERY: Erythromycin, AMP: Ampicillin and CEF Cefepime; The values in bold represent the cases of synergy between extract and antibiotic.