| 5 min pre-dose of DA-9801 (n = 5) | 2 h pre-dose of DA-9801 (n = 5) | ||
---|---|---|---|---|
 | Control | DA-9801 | Control | DA-9801 |
Tmax (h) | 0.600 ± 0.518 | 1.35 ± 0.602 | 0.250 ± 0.000 | 0.550 ± 0.411 |
Cmax (μg/mL) | 1.32 ± 0.330 | 0.896 ± 0.212 | 1.92 ± 0.619 | 1.98 ± 0.364 |
t1/2 (h) | 3.40 ± 1.51 | 3.95 ± 1.09 | 3.40 ± 1.43 | 3.06 ± 0.920 |
AUC8h (μg/mL · h) | 4.00 ± 1.02 | 4.94 ± 2.58 | 4.67 ± 0.819 | 5.96 ± 1.11 |
AUC∞ (μg/mL · h) | 4.91 ± 1.29 | 5.61 ± 1.09 | 5.59 ± 0.528 | 7.37 ± 1.08 |
CL/F (mL/min/kg) | 36.7 ± 13.5 | 30.5 ± 5.46 | 30.0 ± 2.73 | 23.0 ± 3.72 |
Amount excreted in urine (% of dose) | 20.2 ± 7.19 | 30.4 ± 14.7 | 17.5 ± 6.87 | 25.7 ± 5.70 |