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Table 3 Linear regression analysis for lipid traits in the subgroups of constitutional types

From: Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

   

Combined†

KoGES

KCMS

SNP (allele, gene)

Trait*

Subject

n

Effect (SE) [mg/dL]

P-value‡

n

Effect (SE) [mg/dL]

P-value‡

n

Effect (SE) [mg/dL]

P-value‡

rs4149270

HDLC

TE

2646

-0.717 (0.301)

0.0171

1821

-0.728 (0.371)

4.97 × 10-2

825

-0.695 (0.514)

0.177

(C>T, ABCA1)

 

NTE

2658

-1.144 (0.367)

1.82 × 10-3

1822

-1.173 (0.453)

9.60 × 10-3

836

-1.088 (0.627)

0.0802

rs10889353

TG

TE

2656

-0.018 (0.008)

0.0233

1823

-0.020 (0.010)

4.35 × 10-2

833

-0.015 (0.014)

0.286

(A>C, ANGPTL3)

 

NTE

2658

-0.023 (0.008)

2.33 × 10 -3

1824

-0.022 (0.010)

2.35 × 10 -2

834

-0.026 (0.013)

4.04 × 10 -2

rs6589566

TG

TE

2656

0.047 (0.007)

8.90 × 10 -11

1820

0.047 (0.009)

2.09 × 10 -7

836

0.049 (0.013)

1.22 × 10 -4

(A>G, APOA5)

 

NTE

2654

0.034 (0.007)

3.09 × 10 -6

1823

0.030 (0.009)

1.04 × 10 -3

831

0.042 (0.012)

6.99 × 10 -4

 

HDLC

TE

2656

-0.655 (0.350)

0.0615

1820

-0.698 (0.436)

0.110

836

-0.577 (0.589)

0.328

  

NTE

2654

-1.519 (0.440)

5.55 × 10 -4

1823

-1.381 (0.539)

1.05 × 10 -2

831

-1.795 (0.762)

1.87 × 10 -2

rs4420638

LDLC

TE

2659

6.028 (1.399)

1.63 × 10 -5

1821

5.713 (1.731)

9.86 × 10 -4

838

6.619 (2.373)

5.40 × 10 -4

(T>C, APOC1)

 

NTE

2654

2.789 (1.334)

0.0365

1820

3.027 (1.662)

0.0687

834

2.358 (2.236)

0.292

rs261332

HDLC

TE

2658

1.026 (0.349)

3.29 × 10-3

1820

0.573 (0.436)

0.189

838

1.835 (0.583)

1.70 × 10-3

(G>A, LIPC)

 

NTE

2655

1.931 (0.434)

8.51 × 10-6

1821

2.204 (0.529)

3.21 × 10-5

834

1.369 (0.758)

0.0713

rs2156552

HDLC

TE

2660

-1.102 (0.386)

4.28 × 10 -3

1823

-0.961 (0.477)

4.41 × 10 -2

837

-1.370 (0.656)

3.72 × 10 -2

(A>T, LIPG)

 

NTE

2657

-1.049 (0.478)

0.0283

1824

-1.383 (0.596)

2.03 × 10-2

833

-0.441 (0.804)

0.583

rs6586891

TG

TE

2661

-0.015 (0.006)

0.0229

1824

-0.012 (0.008)

0.131

837

-0.021 (0.011)

0.0685

(C>A, LPL)

 

NTE

2656

-0.018 (0.006)

3.38 × 10-3

1824

-0.017 (0.008)

2.81 × 10-2

832

-0.020 (0.010)

0.0517

 

HDLC

TE

2661

0.897 (0.309)

3.71 × 10-3

1824

0.718 (0.379)

0.0584

837

1.251 (0.534)

1.93 × 10-2

  

NTE

2656

1.404 (0.378)

2.00 × 10 -4

1824

1.046 (0.472)

2.68 × 10 -2

832

2.041 (0.629)

1.23 × 10 -3

  1. *Triglyceride (TG): log-transformed.
  2. †Combined: combined meta-analysis of association signals in the KoGES and KCMS populations in a fixed effect model.
  3. ‡Superscript p-values indicate significant associations. Significance: p < 0.005 (0.05/10 SNPs) in the combined population; p < 0.05 in the KoGES and KCMS populations.
  4. Boldface letters indicate reproducible associations in all three populations.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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