Table 2 Linear regression analysis for lipid traits in the Korean population
Combined† | KoGES | KCMS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
SNP (allele, gene) | MAF | Trait* | n | Effect (SE) [mg/dL] | P-value‡ | n | Effect (SE) [mg/dL] | P-value‡ | n | Effect (SE) [mg/dL] | P-value‡ |
rs4149270 (C>T, ABCA1) | 0.348 | HDLC | 8554 | -0.956 (0.187) | 3.10 × 10 -7 | 5528 | -0.806 (0.236) | 6.51 × 10 -4 | 3026 | -1.205 (0.305) | 7.93 × 10 -5 |
rs10889353 (A>C, ANGPTL3) | 0.173 | TG | 8575 | -0.018 (0.004) | 3.25 × 10-5 | 5536 | -0.021 (0.005) | 1.18 × 10-4 | 3039 | -0.013 (0.007) | 0.0739 |
rs1748195 (C>G, ANGPTL3) | 0.221 | TG | 8582 | -0.016 (0.004) | 6.28 × 10 -5 | 5536 | -0.018 (0.005) | 4.83 × 10 -4 | 3046 | -0.013 (0.007) | 4.36 × 10 -2 |
rs6589566 (A>G, APOA5) | 0.217 | TG | 8569 | 0.044 (0.004) | < 2.0 × 10 -16 | 5528 | 0.043 (0.005) | < 2.0 × 10 -16 | 3041 | 0.046 (0.007) | 7.25 × 10 -12 |
HDLC | 8569 | -0.963 (0.220) | 1.22 × 10 -5 | 5528 | -0.935 (0.278) | 7.65 × 10 -4 | 3041 | -1.009 (0.361) | 5.19 × 10 -3 | ||
rs4420638 (T>C, APOC1) | 0.115 | LDLC | 8579 | 4.103 (0.752) | 4.87 × 10 -8 | 5528 | 4.287 (0.951) | 6.61 × 10 -6 | 3051 | 3.796 (1.230) | 2.04 × 10 -3 |
TG | 8579 | 0.018 (0.005) | 4.80 × 10 -4 | 5528 | 0.016 (0.0006) | 1.47 × 10 -2 | 3051 | 0.023 (0.009) | 1.01 × 10 -2 | ||
HDLC | 8579 | -1.108 (0.283) | 8.87 × 10 -5 | 5528 | -0.983 (0.353) | 5.41 × 10 -3 | 3051 | -1.329 (0.283) | 4.80 × 10 -3 | ||
rs174547 (T>C, FADS1) | 0.330 | TG | 8575 | 0.014 (0.004) | 6.25 × 10 -5 | 5533 | 0.014 (0.004) | 1.45 × 10 -3 | 3042 | 0.014 (0.006) | 1.54 × 10 -2 |
rs3846663 (T>C, HMGCR) | 0.473 | LDLC | 8587 | -1.871 (0.477) | 8.75 × 10 -5 | 5537 | -1.872 (0.611) | 2.21 × 10 -3 | 3050 | -1.871 (0.763) | 1.42 × 10 -2 |
rs261332 (G>A, LIPC) | 0.215 | TG | 8578 | 0.014 (0.004) | 8.84 × 10 -4 | 5528 | 0.012 (0.005) | 1.51 × 10 -2 | 3050 | 0.015 (0.007) | 2.17 × 10 -2 |
HDLC | 8578 | 1.233 (0.219) | 1.90 × 10 -8 | 5528 | 1.124 (0.278) | 5.36 × 10 -5 | 3050 | 1.413 (0.357) | 7.78 × 10 -5 | ||
rs2156552 (A>T, LIPG) | 0.164 | HDLC | 8583 | -0.884 (0.242) | 2.61 × 10-4 | 5536 | -1.019 (0.309) | 9.84 × 10-4 | 3047 | -0.670 (0.390) | 0.0858 |
rs1919484 (G>A, LPL) | 0.208 | TG | 8577 | -0.019 (0.004) | 3.68 × 10 -6 | 5535 | -0.016 (0.005) | 2.12 × 10 -3 | 3042 | -0.025 (0.007) | 3.02 × 10 -4 |
HDLC | 8577 | 1.062 (0.220) | 1.45 × 10 -6 | 5535 | 0.733 (0.277) | 8.04 × 10 -3 | 3042 | 1.633 (0.365) | 7.85 × 10 -6 | ||
rs6586891 (C>A, LPL) | 0.325 | TG | 8579 | -0.016 (0.004) | 5.56 × 10 -6 | 5536 | -0.015 (0.004) | 7.91 × 10 -4 | 3043 | -0.018 (0.006) | 2.04 × 10 -3 |
HDLC | 8579 | 1.096 (0.191) | 9.39 × 10 -9 | 5536 | 1.031 (0.242) | 2.13 × 10 -5 | 3043 | 1.203 (0.310) | 1.07 × 10 -4 | ||
rs17321515 (G>A, TRIB1) | 0.439 | TG | 8573 | 0.013 (0.003) | 1.59 × 10-4 | 5528 | 0.015 (0.0004) | 3.19 × 10-4 | 3045 | 0.008 (0.006) | 0.136 |