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Table 4 Biochemical and hematological parameters of Swiss mice exposed to the EAF fraction of A. sylvatica in the acute toxicity study

From: Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic

Parameters Control 500 mg kg-1 1000 mg kg-1 2000 mg kg-1 p*
Creatinine (mg/dL) 0.29 ± 0.03 0.29 ± 0.07 0.28 ± 0.06 0.28 ± 0.05 0.8100
Urea (mg/dL) 43.66 ± 4.27 44.33 ± 4.41 45 ± 5.03 42.5 ± 4.23 0.6391
AST (U/L) 76 ± 4.45 78 ± 5.91 77 ± 4.94 79 ± 4.99 0.9015
ALT (U/L 52.5 ± 4.27 48.5 ± 4.37 50 ± 4.27 53 ± 4.75 0.1990
γ GT (U/L) 11 ± 1.41 11.5 ± 1.37 11 ± 1.26 12 ± 12.6 0.5218
RBC (x 106/mm3) 7.06 ± 0.12 7.11 ± 0.11 7.1 ± 0.10 7.15 ± 0.08 0.6161
HT (%) 45.33 ± 3.66 44.68 ± 3.55 44.5 ± 2.81 45.16 ± 3.9 0.9721
WBC (%) 8.16 ± 0.75 8.33 ± 1.03 8 ± 0.63 8.33 ± 0.81 0.4138
PLT (x 103/μL) 916 ± 10.78 928 ± 9.77 928.66 ± 27 925.16 ± 13 0.5353
LYNF (%) 77 ± 1.63 71±1.36 77.83 ± 0.89 79 ± 2.06 0.4913
NEUT (%) 19.16 ± 1.02 20 ± 1.69 19 ± 0.13 17 ± 1.14 0.5783
  1. Hematological and biochemical parameters of female Swiss mice treated acutely orally with vehicle (control) or the EAF fraction of A. sylvatica at doses of 500 mg kg-1 1000 mg kg-1 and 2000 mg kg-1 Values represent the mean ± SD. (n=6) is the number of animals in each group. p*=5%.
  2. AST = Aspartate aminotransferase.
  3. ALT = Alanine aminotransferase.
  4. γ GT = Gamma glutamyl transferase.
  5. RBC = Red Blood Cell.
  6. HT = Hematocrite.
  7. WBC = White Blood Cell.
  8. PLT= Platelets.
  9. LYNF = Lymphocytes.
  10. NEUT = Neutrophils.