Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic

Table 3 Body weight and relative weights of organs of animals exposed to EAF fraction

Parameters	Control	500 mg kg^-1	1000 mg kg^-1	2000 mg kg^-1	p*
Corporeal weight	21.09 ± 1.31	23.24 ± 1.71	22.24 ± 0.64	23.08 ± 0.74	0.0205
Liver	6.31 ± 0.45	5.98 ± 0.32	5.96 ± 0.70	5.89 ± 0.55	0.5294
Lungs	0.64 ± 0.06	0.56 ± 0.03	0.67 ± 0.15	0.68 ± 0.07	0.1458
Heart	0.47 ± 0.06	0.42 ± 0.02	0.43 ± 0.03	0.48 ± 0.03	0.0666
Right kidney	0.53 ± 0.05	0.58 ± 0.02	0.57 ± 0.05	0.57 ± 0.02	0.1773
Left kidney	0.56 ± 0.03	0.56 ± 0.02	0.59 ± 0.04	0.54 ± 0.08	0.7158
Spleen	0.53 ± 0.19	0.43 ± 0.02	0.48 ± 0.03	0.46 ± 0.04	0.5074

Relative weight (%) of the liver, lung, heart, right kidney, left kidney and spleen of female Swiss mice treated with 500, 1000 and 2000 mg kg^-1 of the EAF fraction of A. sylvatica. Data are expressed as the mean ± standard deviation SISVAR 5.3[25]. (n=6) is the number of animals in each group. p*=5%.