The levels in cortex (nmol/mg protein for ACh and choline, ng/g protein for other transmitters) | |||||||
---|---|---|---|---|---|---|---|
ACh | Choline | MHPG | NE | DOPAC | HVA | DA | |
Vehicle | 224.25 ± 25.55** | 629.00 ± 98.35 | 26.35 ± 2.72 | 15.68 ± 0.76 | 16.75 ± 1.70* | 3.71 ± 0.58 | 3.92 ± 0.44** |
Aβ 1-42 | 141.35 ± 7.95 | 553.10 ± 31.55 | 23.27 ± 1.97 | 13.86 ± 1.29 | 11.66 ± 1.13 | 2.76 ± 0.43 | 2.33 ± 0.28 |
CT extract | |||||||
100 mg/kg | 145.98 ± 18.78 | 716.40 ± 69.81 | 29.91 ± 4.91 | 15.94 ± 1.30 | 13.89 ± 3.03 | 4.29 ± 0.93 | 2.95 ± 0.65 |
200 mg/kg | 181.49 ± 13.71* | 693.45 ± 48.05 | 24.51 ± 4.16 | 10.31 ± 1.07 | 9.50 ± 2.10 | 2.98 ± 0.85 | 2.23 ± 0.33 |
Donepezil | 168.32 ± 6.58* | 467.26 ± 32.85 | 15.16 ± 2.51* | 10.73 ± 2.33 | 10.49 ± 2.38 | 2.42 ± 0.78 | 3.10 ± 0.46 |
The levels in hippocampus (nmol/mg protein for ACh and choline, ng/g protein for other transmitters) | |||||||
ACh | Choline | MHPG | NE | DOPAC | HVA | DA | |
Vehicle | 72.88 ± 8.64*** | 295.26 ± 18.06** | 639.83 ± 53.38 | 63.64 ± 2.56* | 5.87 ± 0.92 | 3.68 ± 0.41 | 5.36 ± 0.75*** |
Aβ 1-42 | 28.45 ± 2.62 | 173.10 ± 18.15 | 639.23 ± 68.26 | 52.67 ± 4.21 | 5.13 ± 0.80 | 3.39 ± 0.36 | 1.00 ± 0.21 |
CT extract | |||||||
100 mg/kg | 43.48 ± 3.14 | 238.20 ± 23.91 | 785.42 ± 139.84 | 57.98 ± 10.69 | 4.98 ± 0.78 | 3.90 ± 0.61 | 2.40 ± 0.65* |
200 mg/kg | 50.44 ± 8.98* | 234.69 ± 13.26 | 704.84 ± 59.68 | 63.21 ± 4.79 | 5.98 ± 1.90 | 3.78 ± 0.64 | 3.09 ± 1.27* |
Donepezil | 51.11 ± 9.54* | 177.69 ± 46.80 | 455.27 ± 46.81* | 32.80 ± 3.88*** | 3.19 ± 1.00 | 2.45 ± 0.33 | 1.33 ± 0.37 |