Figure 3
From: Antihyperglycemic action of rhodiola-aqeous extract in type1-like diabetic rats
Effect of opioid μ-receptor blockade on rhodiola-water extract-induced changes of GLUT 4 in skeletal muscle and hepatic PEPCK in STZ-diabetic rats. (A) The mRNA level of GLUT 4 in skeletal muscle isolated from STZ-diabetic rats receiving treatment with rhodiola-water extract only or with cyprodime in combination, three times daily for 3 days. (B) The mRNA level of PEPCK expression in liver isolated from STZ-diabetic rats receiving same treatment with rhodiola-water extract only or with cyprodime in combination. The samples were then collected for qRT-PCR analysis. Lane1, vehicle-treated Wistar rats; lane2, vehicle-treated STZ-diabetic rats; lane 3, rhodiola-water extract (75 mg/kg)-treated STZ-diabetic rats; lane 4, rhodiola-water extract (75 mg/kg) plus cyprodime (1.0 mg/kg)-treated STZ-diabetic rats. Data are expressed as mean with standard error (SE) (n = 6 per group) is indicated in each column. ***, p < 0.001 compared with data obtained from lane 1. ##, p < 0.01 and ###, p < 0.001 compared with data obtained from lane 2.