Figure 7From: Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways Proposed schematic diagram of the mechanism by which DCM-DS induced apoptosis in caspase-3 deficient MCF-7 cells. DCM-DS induced cell cycle arrest in MCF-7 cells. In addition, DCM-DS up-regulated NF-κB, JNK1 and down-regulated AKT1, ERK1, resulting in apoptosis in caspase-3 deficient MCF-7 cells.Back to article page