Table 3 KEGG pathway (FDR < 0.001, Fold enrichment > 2.0)
From: Berberine moderates glucose metabolism through the GnRH-GLP-1 and MAPK pathways in the intestine
KEGG_ID | Term | Count | Total number of genes in the pathway | Fold enrichment | FDR | Genes |
|---|---|---|---|---|---|---|
rno04010 | MAPK signaling pathway | 95 | 266 | 17.985 | 3.26E-19 | RGD1565395, HRAS, PDGFA, TGFB3, NFKB1, FGF12, NFKB2, DAXX, TGFB1, TGFB2, AKT1, CDC42, FOS, CASP3, MOS, RRAS, PRKACA, PRKACB, FAS, MAP2K7, AKT3, AKT2, MAP2K5, EGFR, PRKCA, RELA, PTPRR, TP53, FLNC, ECSIT, FLNB, PRKCB, MAPK1, MAP4K4, RASGRF1, JUN, MAPK3, PDGFRA, HSPB1, MAPK9, PDGFRB, MAPK8, MAP3K14, GADD45A, FGFR2, FGFR1, TRAF2, GRB2, MRAS, MAPKAPK5, MKNK2, DUSP10, ELK1, HSPA1A, HSPA1B, MAPKAPK2, HSPA1L, TNFRSF1A, HSPA2, ELK4, SOS1, SOS2, DUSP16, RAC1, PPP3CB, PPP3CC, PPP3CA, CHP, HSPA8, PTPN7, MAP2K1, MAP2K2, PTPN5, MAP2K3, NLK, MAP2K4, TAOK3, NR4A1, RAF1, MAPK10, DUSP5, NRAS, DUSP4, DUSP3, ATF4, DUSP2, DUSP1, MAPK14, NTRK2, IKBKG, MAPK8IP3, DUSP9, IKBKB, CRK, DUSP7, DUSP6 |
rno04912 | GnRH signaling pathway | 42 | 94 | 22.501 | 1.01E-13 | ADCY3, ADCY4, ADCY1, HRAS, ADCY2, ADCY7, GRB2, ADCY5, GNA11, ADCY6, ELK1, GNRHR, MMP2, CDC42, PTK2B, SOS1, SOS2, PRKACA, PRKACB, MAP2K7, EGFR, PRKCA, GNRH1, MAP2K1, MAP2K2, MAP2K3, MAP2K4, RAF1, MAPK10, MMP14, PRKCD, PRKCB, MAPK1, NRAS, ATF4, GNAQ, ADCY9, JUN, MAPK14, MAPK3, MAPK9, MAPK8 |
rno04540 | Gap junction | 29 | 81 | 18.030 | 9.06E-11 | ADCY3, ADCY4, ADCY1, HRAS, ADCY2, ADCY7, PDGFA, GRB2, ADCY5, GNA11, ADCY6, SOS1, SOS2, PRKACA, PRKACB, MAP2K5, PRKCA, EGFR, MAP2K1, MAP2K2, RAF1, PRKCB, NRAS, MAPK1, ADCY9, GNAQ, MAPK3, PDGFRA, PDGFRB |
rno04722 | Neurotrophin signaling pathway | 31 | 126 | 12.390 | 2.14E-09 | HRAS, GRB2, NFKB1, MAPKAPK2, AKT1, CDC42, SOS1, RAC1, SOS2, MAP2K7, AKT3, AKT2, MAP2K5, MAP2K1, MAP2K2, RELA, TP53, RAF1, MAPK10, PRKCD, NRAS, MAPK1, ATF4, JUN, MAPK14, MAPK3, NTRK2, MAPK9, MAPK8, IKBKB, CRK |
rno05200 | Pathways in cancer | 43 | 317 | 6.831 | 4.57E-08 | FGFR2, TRAF2, FGFR1, HRAS, PDGFA, GRB2, TGFB3, NFKB1, FGF12, NFKB2, MMP2, TGFB1, TGFB2, AKT1, CDC42, FOS, CASP3, SOS1, SOS2, RAC1, FAS, AKT3, AKT2, EGFR, PRKCA, MAP2K1, MAP2K2, RELA, TP53, RAF1, MAPK10, PRKCB, MAPK1, NRAS, JUN, IKBKG, MAPK3, PDGFRA, PDGFRB, MAPK9, MAPK8, IKBKB, CRK |
rno04662 | B cell receptor signaling pathway | 25 | 75 | 16.786 | 9.81E-07 | HRAS, GRB2, NFKB1, AKT1, FOS, SOS1, RAC1, SOS2, PPP3CB, PPP3CC, CHP, PPP3CA, AKT3, AKT2, MAP2K1, MAP2K2, RELA, RAF1, PRKCB, NRAS, MAPK1, JUN, MAPK3, IKBKG, IKBKB |
rno04660 | T cell receptor signaling pathway | 28 | 109 | 12.936 | 2.43E-06 | HRAS, GRB2, NFKB1, AKT1, CDC42, FOS, SOS1, SOS2, PPP3CB, PPP3CC, PPP3CA, CHP, MAP2K7, AKT3, AKT2, MAP2K1, MAP2K2, RELA, RAF1, NRAS, MAPK1, JUN, MAPK14, IKBKG, MAPK3, MAPK9, IKBKB, MAP3K14 |
rno04062 | Chemokine signaling pathway | 32 | 171 | 9.424 | 2.04E-05 | ADCY3, ADCY4, ADCY1, HRAS, ADCY2, ADCY7, GRB2, ADCY5, ADCY6, NFKB1, AKT1, CDC42, PTK2B, SOS1, SOS2, RAC1, PRKACA, PRKACB, AKT3, AKT2, MAP2K1, RELA, RAF1, PRKCD, PRKCB, NRAS, MAPK1, ADCY9, IKBKG, MAPK3, IKBKB, CRK |
rno05215 | Prostate cancer | 25 | 90 | 13.988 | 1.32E-04 | FGFR2, FGFR1, HRAS, PDGFA, GRB2, NFKB1, AKT1, SOS1, SOS2, AKT3, AKT2, EGFR, MAP2K1, MAP2K2, RELA, TP53, RAF1, NRAS, MAPK1, ATF4, IKBKG, MAPK3, PDGFRA, PDGFRB, IKBKB |