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Table 2 Effect of JSOG-6 on the serum parameters in OVX mice

From: Effects of JSOG-6 on protection against bone loss in ovariectomized mice through regulation of osteoblast differentiation and osteoclast formation

 

Calcium concentration

Potassium concentration

ALP activity

TRAP activity

Osteocalcin level

CTx level

Sham

9.1 ± 0.4

8.0 ± 0.3

67.6 ± 2.8

9.1 ± 0.9

148.9 ± 5.3

69.5 ± 4.3

OVX

9.3 ± 0.3

8.3 ± 0.4

85.0 ± 3.1

19.8 ± 1.0

176.9 ± 4.7

95.7 ± 3.8

E2

9.1 ± 0.6

7.9 ± 0.2

59.9 ± 3.1*

10.8 ± 1.0*

141.9 ± 4.9*

76.6 ± 4.7*

JSOG-6

      

50 mg/kg

9.4 ± 0.5

7.9 ± 0.3

59.3 ± 3.8*

11.6 ± 1.4*

165.0 ± 6.6

92.3 ± 3.6

150 mg/kg

9.4 ± 0.6

7.9 ± 0.3

62.8 ± 4.6*

9.7 ± 1.1*

155.8 ± 5.1*

89.7 ± 5.2

450 mg/kg

9.6 ± 0.4

8.1 ± 0.4

65.9 ± 3.4*

8.3 ± 0.7*

153.0 ± 5.3*

83.6 ± 3.8*

  1. The serum levels of calcium, potassium, ALP, CTx, OCN, and TARP were analyzed as described in the Methods. Data represent the mean ± S.D. (n = 8). *P < 0.01 indicates statistically significant differences from the OVX mice group.