Samples | Dose mg/kg | Tail withdrawing time in sec | ||||
---|---|---|---|---|---|---|
 |  | 0 min | 30 min | 60 min | 90 min | 120 min |
1% tween 80 | 10 ml/kg | 3.45 ± 0.26 | 3.48 ± 0.19ns | 3.27 ± 0.032ns | 3.48 ± 0.20ns | 3.57 ± 0.19 |
METS | 50 mg/kg | 3.48 ± 0.19 | 3.57 ± 0.19ns | 4.11 ± 0.12ns | 4.16 ± 0.12ns | 4.09 ± 0.11ns |
100 mg/kg | 3.53 ± 0.18 | 4.25 ± 0.04ns | 4.49 ± 0.13ns | 4.39 ± 0.08ns | 4.29 ± 0.04ns | |
150 mg/kg | 3.57 ± 0.19 | 4.82 ± 0.04ns | 5.48 ± 0.02ns | 5.27 ± 0.05ns | 5.18 ± 0.06ns | |
TramadolR | 30 mg/kg | 3.48 ± 0.20 | 4.99 ± 0.33 | 5.69 ± 0.02 | 5.49 ± 0.06ns | 5.38 ± 0.05ns |
Antinociceptive effect of METS and TramadolR antagonized by Naloxone | ||||||
METS | 150 mg/kg | 3.52 ± 0.02 ns | 2.64 ± 0.01ns | 2.87 ± 0.02ns | 2.73 ± 0.01ns | 2.69 ± 0.01ns |
TramadolR | 30 mg/kg | 3.50 ± 0.02 | 2.35 ± 0.02 | 2.69 ± 0.01 | 2.75 ± 0.02 | 2.65 ± 0.02 |