Table 2 Cytotoxicity and antiviral activity of ellagic acid and antiviral agent ribavirin toward human rhinovirus-4 in HeLa cells using sulforhodamine B bioassay
Compound | Â | HRV-2 | HRV-3 | HRV-4 | |||
|---|---|---|---|---|---|---|---|
|  | CC50(μg/mL) | IC50(μg/mL) (±SD) | TIa | IC50(μg/mL) (±SD) | TIa | IC50(μg/mL) (±SD) | TIa |
Natural EAb | >100 | 38 ± 3.2b | >2.6 | 31 ± 5.2b | >3.2 | 29 ± 2.5b | >3.4 |
Pure EA | >100 | 41 ± 1.1b | >2.4 | 30 ± 2.4b | >3.3 | 29 ± 1.7b | >3.4 |
Ribavirin | >100 | 70 ± 4.9a | >1.4 | 71 ± 0.5a | >1.4 | 63 ± 5.6a | >1.6 |