Antiviral activity and possible mode of action of ellagic acid identified in Lagerstroemia speciosa leaves toward human rhinoviruses

Table 1 Cytotoxicity and antiviral activity of fractions obtained from the solvent partitionings of the methanol extract of L. speciosa leaves toward human rhinovirus-4 in HeLa cells using sulforhodamine B bioassay

Test material	CC₅₀(μg/mL)	IC₅₀(μg/mL) (±SD)	TI^a
Methanol extract	1036	82 ± 1.8^d	12.6
Hexane-soluble fraction	1074	777 ± 5.8^b	1.4
Ethyl acetate-soluble fraction	1675	71 ± 1.0^d	23.5
Butanol-soluble fraction	1260	881 ± 8.7^a	1.4
Water-soluble fraction	1409	607 ± 3.5^c	2.3

Means within a column followed by the same letter are not significantly different (P = 0.05, Bonferroni method).
^aTherapeutic index = CC₅₀/IC₅₀.

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