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Table 4 Primary endpoint-Serum biomarkers levels

From: Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial

  Coll2-1 (nmol/L) Coll2-1NO2(nmol/L) Fib3-1 (pmol/L) Fib3-2 (pmol/L) CRP (mg/L) Cartilaps (ng/L) MPO (μg/L)
V1 302.21 ± 53.78 0.71 ± 0.18 707.05 ± 178.79 580.58 ± 103.09 10.42 ± 30.27 11.81 ± 7.98 27.20 ± 29.05
V3 315.37 ± 62.35 0.77 ± 0.20 736.05 ± 157.16 600.90 ± 86.04 3.82 ± 3.29 12.12 ± 5.98 20.46 ± 13.15
V5 257.84 ± 52.78 0.80 ± 0.24 765.20 ± 261.90 636.74 ± 119.73 3.10 ± 2.40 13.17 ± 4.96 21.96 ± 14.65
P = 0.002*
  1. *p value versus V1. Data are mean ± sd and were analyzed with Student t-test. V1: first visit, at the time of selection; V3: visit after 14 days of treatment; V5: visit after 84 days of treatment.