Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial

Table 4 Primary endpoint-Serum biomarkers levels

	Coll2-1 (nmol/L)	Coll2-1NO₂(nmol/L)	Fib3-1 (pmol/L)	Fib3-2 (pmol/L)	CRP (mg/L)	Cartilaps (ng/L)	MPO (μg/L)
V1	302.21 ± 53.78	0.71 ± 0.18	707.05 ± 178.79	580.58 ± 103.09	10.42 ± 30.27	11.81 ± 7.98	27.20 ± 29.05
V3	315.37 ± 62.35	0.77 ± 0.20	736.05 ± 157.16	600.90 ± 86.04	3.82 ± 3.29	12.12 ± 5.98	20.46 ± 13.15
V5	257.84 ± 52.78	0.80 ± 0.24	765.20 ± 261.90	636.74 ± 119.73	3.10 ± 2.40	13.17 ± 4.96	21.96 ± 14.65
V5	P = 0.002*	0.80 ± 0.24	765.20 ± 261.90	636.74 ± 119.73	3.10 ± 2.40	13.17 ± 4.96	21.96 ± 14.65

*p value versus V1. Data are mean ± sd and were analyzed with Student t-test. V1: first visit, at the time of selection; V3: visit after 14 days of treatment; V5: visit after 84 days of treatment.

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