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Table 1 α- glucosidase and α-amylase inhibition activity of Compounds 1, 2 and 3

From: Target guided isolation, in-vitro antidiabetic, antioxidant activity and molecular docking studies of some flavonoids from Albizzia Lebbeck Benth. bark

Samples

Inhibition (%)

α-Glucosidase from saccharomyces cerevisiae

α-Amylase from bacillus subtilis

Compound 1 (7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one)

93.91 ± 1.21***

93.98 ± 1.02***

Compound 2 ((S)-2-(3,4-dihydroxyphenyl)-7,8-dihydroxychroman-4-one)

73.14 ± 1.30**

84.36 ± 0.60***

Compound 3 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one)

92.59 ± 1.36***

90.10 ± 0.58***

Acarbose

43.77 ± 1.67

37.65 ± 0.94

  1. Statistically significant differences are designated by asterisks and double asterisks (***p < 0.001, **p < 0.01 compared to acarbose).