Phytochemical constituents, nutritional values, phenolics, flavonols, flavonoids, antioxidant and cytotoxicity studies on Phaleria macrocarpa (Scheff.) Boerl fruits

Table 6 In vitro , cytotoxic effects of methanol extract and its fractions of P. macrocarpa fruits on Ca Ski, MCF-7, HT-29, SKOV3 and MDA-MB231 cancer cells lines

Extract		ME	HF	CF	EAF	WF
Cell line	hr
	24	≥100^a	≥100^a	≥100^a	≥100^a	≥100^a
Ca Ski	48	≥100^a	≥100^a	≥100^a	≥100^a	≥100^a
	72	≥100^a	≥100^a	≥100^a	≥100^a	≥100^a
	24	≥100^a	≥100^a	36.3^c±2.76	16.5^c±2.45	≥100^a
MCF-7	48	≥100^a	44.1^b±2.38	85.5^b±1.76	23.0^b±3.44	≥100^a
	72	≥100^a	≥100^a	≥100^a	43.5^a±4.03	≥100^a
	24	96^a±2.92	81.5^a±3.0	41.2^a±3.66	32.1^bc±2.32	≥100^a
HT-29	48	83.5^ab±2.52	60.0^b±2.33	44.0^a±3.76	44.5^b±1.29	≥100^a
	72	38.5^b±1.82	68.1^b±3.75	37.0^ab±2.65	83.5^a±2.52	≥100^a
	24	80.0^a±2.44	10.15^b±2.71	35.0^b±1.11	46.0^a±1.14	≥100^a
SKOV-3	48	68.1^ab±1.81	69.0^a±2.56	37.5^b±1.62	21.85^b±2.58	≥100^a
	72	7.75^c±2.56	72.5^a±3.13	80.0^a±4.56	8.1^c±1.81	≥100^a
	24	20.3^b±3.71	5.8^b±2.15	14.6^a±1.45	6.8^b±2.08	≥100^a
MDA-MB231	48	34.6^b±1.83	4.6^b±1.32	7.8^b±1.57	6.4^b±1.09	≥100^a
	72	95^a±2.11	34.3^a±2.19	15.3^a±1.72	16.2^a±2.4	≥100^a

(ME: Methanol Extract; HF: Hexane Fraction; CF: Chloroform Fraction; EAF: Ethyl Acetate Fractions; WF: Water Fraction); The means of the extracts with same small letters were not significantly different as per Duncan’s multi-range test at P < 0.05.

ISSN: 2662-7671