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Table 2 Effect of hydromethanolic crude extract of aerial parts of A. abyssinica on parasitaemia and mean survival time of T. congolense infected mice

From: Evaluation of in vivo antitrypanosomal activity of crude extracts of Artemisia abyssinica against aTrypanosoma congolense isolate

Treatment

Dose (mg/kg)

Parasitaemia level (log number)/ml

Mean survival time (days)

D0

D2

D4

D6

D8

D10

D12

D14

80% MeOH ext

100

7.16 ± 0.18

8.10 ± 0.17

7.80 ± 0.28bc

7.92 ± 0.26bcd

7.88 ± 0.16c

8.23 ± 0.21c

7.82 ± 0.16c

8.45 ± 0.13c

35.17 ± 6.49

80% MeOH ext

200

7.02 ± 0.09

7.90 ± 0.08

7.57 ± 0.24bc

6.90 ± 0.49c

6.70 ± 0.47c

7.95 ± 0.24c

7.69 ± 0.33c

8.10 ± 0.27c

36.50 ± 5.09

80% MeOH ext

400

7.17 ± 0.32

7.83 ± 0.28

6.05 ± 0.36bc

3.00 ± 1.36a

3.87 ± 1.37a

4.90 ± 1.00ac

7.30 ± 0.12c

7.15 ± 0.31c

38.17 ± 4.88

DA

3.5

7.09 ± 0.06

1.25 ± 1.25

1.90 ± 1.20ad

3.30 ± 1.48a

4.60 ± 1.48c

6.12 ± 1.26c

7.41 ± 0.40c

7.92 ± 0.27c

36.83 ± 4.36

DA

28

7.13 ± 0.05

0.00 ± 0.00

0.00 ± 0.00ad

0.00 ± 0.00a

0.00 ± 0.00ab

0.00 ± 0.00e

0.90 ± 0.90e

1.85 ± 1.17e

42.00 ± 0.00

Distilled water

1 ml

6.94 ± 0.26

7.97 ± 0.12

8.67 ± 0.10

8.54 ± 0.07

8.46 ± 0.17

8.70 ± 0.06

8.14 ± 0.27

8.45 ± 0.21

34.33 ± 6.15

  1. Values are mean ± SEM; n = 6; D = day; D0 = the day treatment commenced; SEM = standard error of mean; MeOH = Methanol; ext = extract; DA = Diminazene aceturate; All superscripts indicate significance at p < 0.05 (a = compared to negative control; b = compared to 3.5 mg/kg DA; c = compared to 28 mg/kg DA; d = compared to 400 mg/kg; e = compared to all groups).