Treatment | Dose (mg/kg) | Parasitaemia level (log number)/ml | Mean survival time (days) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
D0 | D2 | D4 | D6 | D8 | D10 | D12 | D14 | |||
80% MeOH ext | 100 | 7.16 ± 0.18 | 8.10 ± 0.17 | 7.80 ± 0.28bc | 7.92 ± 0.26bcd | 7.88 ± 0.16c | 8.23 ± 0.21c | 7.82 ± 0.16c | 8.45 ± 0.13c | 35.17 ± 6.49 |
80% MeOH ext | 200 | 7.02 ± 0.09 | 7.90 ± 0.08 | 7.57 ± 0.24bc | 6.90 ± 0.49c | 6.70 ± 0.47c | 7.95 ± 0.24c | 7.69 ± 0.33c | 8.10 ± 0.27c | 36.50 ± 5.09 |
80% MeOH ext | 400 | 7.17 ± 0.32 | 7.83 ± 0.28 | 6.05 ± 0.36bc | 3.00 ± 1.36a | 3.87 ± 1.37a | 4.90 ± 1.00ac | 7.30 ± 0.12c | 7.15 ± 0.31c | 38.17 ± 4.88 |
DA | 3.5 | 7.09 ± 0.06 | 1.25 ± 1.25 | 1.90 ± 1.20ad | 3.30 ± 1.48a | 4.60 ± 1.48c | 6.12 ± 1.26c | 7.41 ± 0.40c | 7.92 ± 0.27c | 36.83 ± 4.36 |
DA | 28 | 7.13 ± 0.05 | 0.00 ± 0.00 | 0.00 ± 0.00ad | 0.00 ± 0.00a | 0.00 ± 0.00ab | 0.00 ± 0.00e | 0.90 ± 0.90e | 1.85 ± 1.17e | 42.00 ± 0.00 |
Distilled water | 1 ml | 6.94 ± 0.26 | 7.97 ± 0.12 | 8.67 ± 0.10 | 8.54 ± 0.07 | 8.46 ± 0.17 | 8.70 ± 0.06 | 8.14 ± 0.27 | 8.45 ± 0.21 | 34.33 ± 6.15 |