Figure 6

Effects of treatments on NF-κB activity (A) and phosphorylated NF-κB (B) in renal tissues of rats. STZ-diabetic rats treated for eight weeks with ruscogenin (RUS) or rosiglitazone (Rosi). STZ-diabetic rats were dosed by oral gavage once daily for eight weeks with 3 mg/kg RUS (STZ + RUS) or 5 mg/kg RGZ (STZ + Rosi). Normal (normal + Veh) or STZ-diabetic rats receiving vehicle treatment (STZ + Veh) were administered the same volume of vehicle (Veh) used to prepare test medications. The mean density values of p-NF-κB were expressed as ratios relative to that of NF-κB. The level of lamin A was estimated for equal loading of nuclear sample. Values (mean ± SD) were obtained for each group of 5 animals. ^aP < 0.05 and ^bP < 0.01 compared with vehicle-treated normal rats (normal + Veh), respectively. ^cP < 0.05 and ^dP < 0.01 compared to vehicle-treated STZ-diabetic rats (STZ + Veh), respectively.