Antibacterial constituents of three Cameroonian medicinal plants: Garcinia nobilis, Oricia suaveolens and Balsamocitrus camerunensis

Table 2 MBCs of the extracts, compounds from Garcinia nobilis, Oricia suaveolens , Balsmocitrus camerunensis and reference drugs on documented strains and clinical MDR isolates

Tested samples^a	Microorganisms, strains and MBC (μg/ml)^b
	E. coli			E. aerogenes			K. pneumoniae		P. stuartii		P. aeruginosa		M. tuberculosis
	ATCC 10536	AG 100	AG 102	ATCC 13048	CM 64	EA 27	ATCC 11296	KP55	ATCC 29916	NAE 16	PA 01	PA 124	ATCC 27294	MTCS1	MTCS2
Crude extracts
GNB	256	512	>512	>512	>512	>512	256	>512	>512	-	>512	-	256	>512	512
OSR	256	>512	-	>512	-	-	512	512	>512	512	-	-	>512	-	>512
OSW	512	>512	-	-	-	-	256	512	-	512	-	-	512	-	>512
BCB	>512	-	-	512	-	-	>512	>512	-	-	-	-	-	-	-
Compounds
1	>512	>512	-	-	-	-	-	-	-	-	-	-	-	-	-
2	128	256	256	256	>512	128	>512	>512	512	128	128	256	16	64	32
3	256	256	128	512	-	512	-	-	-	-	-	-	128	-	256
4	-	128	256	-	512	256	-	-	-	-	512	-	>512	-	>512
5	128	256	256	-	-	>512	>512	-	>512	-	128	256	64	128	128
8	>512	256	>512	-	>512	256	>512	-	-	-	-	-	256	>512	512
9	-	256	>512	-	512	>512	256	-	-	-	-	-	-	-	-
10	256	256	512	-	-	-	-	-	>512	-	-	-	512	-	>512
11	>512	-	-	-	-	>512	-	-	-	-	-	-	-	-	-
13	>512	128	512	-	>512	256	512	-	-	-	256	>512	512	>512	>512
15	256	512	>512	-	-	512	-	-	-	-	-	-	-	-	-
16	256	256	-	-		>512	-	-	>512	-	-	-	>512	-	-
17	-	256	-	-	-	-	-	-	-	-	-	-	-	-	-
18	-	512	-	-	-	512	-	-	-	512	-	-	-	-	-
19	-	512	-	-	-	-	-	-	-	-	-	-	-	-	-
20	-	>512	-	-	-	-	-	-	-	-	-	-	-	-	-
21	>512	512	-	-	-	512	512	-	-	-	-	-	-	-	-
22	>512	512	512	>512	256	-	-	>512	-	-	-	-	-	-	-
RA	<4	32	>512	128	-	128	8	64	-	128	256	256	2	256	16

^aTested samples [methanol-dichloromethane 1:1 extract of the stem bark of Garcinia nobilis (GNB), the wood (OSW)roots (OSR) of Oricia suaveolens, and stem bark of Balsmocitrus camerunensis (BCB); compounds isolated from the stem bark of Garcinia nobilis (1–5), Oricia suaveolens woods (6–11) and roots (12–17), and the stem back of Balsmocitrus camerunensis (18–22); caroxanthone (1), 4-prenyl-2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone (2), smeathxanthone A (3), 8-hydroxycudraxanthone G (4), morusignin I (5), stigma-5-en-3-ol (6), 20(29)lupen-2-ol (7), evoxanthine (8), norevoxanthine (9), 1-hydoxy-2,3-dimethoxy-10-methylacridone (10), 1,3-dimethoxy-10-methylacridone (11), kokusaginine (13), 1-hydroxy-4-methoxy-10-methylacridone (15), syringaresinol (16), limonin (17), 1-hydroxy-3,6-dimethoxy-8-methylxanthone (18), xanthoxyletin (19), imperatorin (20), 6,8-dimethoxycoumarin (21), umbelliferone (22)]; RA: reference antibiotics were chloramphenicol for bacteria, isoniazid for M. tuberculosis; ^b(−): MBC not determined as the MIC was above 512 μg/ml.

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