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Table 2 Percent inhibiton values of plants crude extracts on three human cancer cell lines at 20 and 200 μg/ml concentrations

From: In vitro anticancer screening of 24 locally used Nigerian medicinal plants

Species

T-549

BT-20

PC-3

 

20 μg/ml

200 μg/ml

20 μg/ml

200 μg/ml

20 μg/ml

200 μg/ml

Acanthus montanus

7 ± 5.01

10 ± 3.45

Nd

27 ± 8.38*

Nd

<5

Allanblackia floribunda

66 ± 6.51*

96 ± 3.48*

21 ± 4.55

80 ± 5.38*

13 ± 0.58

92 ± 5.29*

Amaranthus spinosus

16 ± 3.86

<5

8 ± 1.72

32 ± 8.14

Nd

Nd

Bidens pilosa

23 ± 9.50

97 ± 1.63*

Nd

93 ± 1.73*

35 ± 1.08

95 ± 1.53

Bryophyllum pinnatum

24 ± 6.08

96 ± 1.68*

Nd

81 ± 6.51*

Nd

95 ± 1.62*

Byrsocarpus coccineus Bark

20 ± 2.51

100

Nd

93 ± 2.66*

Nd

97 ± 6.15*

Leaves

54 ± 1.76

100

Nd

100

Nd

100

Cajanus cajan

9 ± 1.46

99 ± 0.58*

<5

99 ± 0.17*

23 ± 1.53

100

Capsicum frutescens

<5

10 ± 0.96

<5

39 ± 3.96

11 ± 2.40

41 ± 1.08

Chromolaena odorata

13 ± 4.21

8 ± 3.06

6 ± 0.81

39 ± 2.12

Nd

Nd

Crassocephalum crepidioides

14 ± 2.14

51 ± 1.04*

Nd

10 ± 5.21

Nd

9 ± 1.01

Daniellia oliveri

35 ± 1.55

97 ± 0.21*

<5

66 ± 4.16*

22 ± 10.50

47 ± 5.78

Erythrophleum suaveolens

100

100

100

100

100

100

Hoslundia opposita

19 ± 0.55

96 ± 0.42*

Nd

93 ± 1.67*

Nd

51 ± 8.21*

Jatropa curcas

45 ± 4.01

100

29 ± 0.61

87 ± 1.52*

Nd

Nd

Landolphia dulcis

83 ±1.39

100

Nd

11 ± 1.21

Nd

9 ± 3.11

Lannea nigritana

32 ± 0.32

90 ± 0.17*

Nd

Nd

Nd

21 ± 7.71*

Ocimum basilicum

<5

<5

<5

<5

<5

Nd

Parkia biglobosa

<5

75 ± 3.36*

7 ± 5.13

72 ± 0.61

17 ± 7.21

93 ± 6.03*

Parkia filicoidea

<5

67 ± 3.06*

<5 27 ± 3.70

10 ± 0.70

76 ± 1.53*

 

Pterocarpus santalinoides

17 ± 2.52

98 ± 0.45*

<5

11 ± 5.03

<5

17 ± 0.40

Rauvolfia vomitoria

<5 37 ± 1.12

19 ± 0.72

33 ± 1.71

<5

8 ± 4.23

 

Sida acuta

91 ± 5.86*

95 ± 3.16*

25 ± 5.03

97 ± 0.57*

27 ± 2.20

97 ± 1.80*

Tetrapleura tetraptera

66 ± 1.38*

100 58 ± 9.13*

100

Nd

Nd

 

Vitex doniana Bark

<5

89 ± 1.27*

Nd

55 ± 1.33

Nd

<5

Root

21 ± 1.46

56 ± 2.35*

Nd

61 ± 1.06

Nd

57 ± 1.25

  1. The antiproliferative/cytotoxic effect is expressed in terms of the percent inhibition of cells growth relative to the DMSO control after 72 h exposure to the extracts. Results are expressed as mean ± SD of three rreplicate experiments. Nd = Not determined. *There was a significant difference in cell inhibition in extract-treated cultures compared with DMSO-control in all cell lines (P<0.05).