Figure 5
Effects LBP on microglia/macrophage activation (polarization) in SCI. Relative numbers of iNOS/Arg1 ratio to the corresponding vehicle controls at the same time point in the same group were shown. In rats treated with LBP-pre, iNOS was up-regulated and Arg1 down-regulated, with consequent higher ratio of iNOS/Arg1, compared to vehicle groups, at both 7 d and 14 d, respectively. Whereas, LBP-aft administration induced both increase in iNOS and Arg1 level, but finally got a reduced iNOS/Arg1 ratio, versus its vehicle control at 14 d. *p < 0.05, compared to the corresponding vehicle control.