Table 4 Percentage (± SE) of motile Onchocerca volvulus microfilariae found in 6.25 μg/ml to 200 μg/ml of Euphorbia hirta and Rauvolfia vomitoria extracts at 24 and 48 hrs
Extract/drug | Extract concentration(μg/ml) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
6.25 (μg/ml) | 12.5 (μg/ml) | 25 (μg/ml) | 50 (μg/ml) | 100 (μg/ml) | 200 (μg/ml) | |||||||
24 hrs | 48 hrs | 24 hrs | 48 hrs | 24 ± hrs | 48 hrs | 24 hrs | 48 hrs | 24 hrs | 48 hrs | 24 hrs | 48 hrs | |
Euphorbia hirta | ||||||||||||
Crude | 73(±19) | 34(±25) | 67 (±21) | 34(±25) | 67(±21) | 25(±25) | 35 (±22) | 0 | 4(±4) | 0 | 4(±4) | 0 |
Hexane | 96(±4) | 62(±20) | 96(±4) | 54(±23) | 78(±13) | 44(±1) | 74(±1) | 44(±1) | 74(±1) | 33(±1) | 38(±31) | 12(±12) |
Chloroform | 77(±12) | 33(±33) | 63(±23) | 33(±33) | 63(±22) | 25(±25) | 20(±20) | 0 | 0 | 0 | 0 | 0 |
Ethyl acetate | 27(±27) | 0 | 27(±27) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aqueous | 65(±19) | 33(±33) | 62(±19) | 33(±33) | 39(±19) | 0 | 23(±17) | 0 | 10(±5) | 0 | 8(±8) | 0 |
Rauvolfia vomitoria | ||||||||||||
Crude | 92(±1) | 33(±33) | 92(±1) | 33(±33) | 92(±1) | 33(±33) | 87(±13) | 33(±33) | 71(±29) | 33(±33) | 67(±33) | 33(±33) |
Hexane | 89(±11) | 33(±33) | 89(±11) | 33(±33) | 80(±1) | 33(±33) | 72(±20) | 33(±33) | 71(±20) | 33(±33) | 46(±27) | 33(±33) |
Chloroform | 100 | 33(±33) | 97(±3) | 33(±33) | 97(±3) | 33(±33) | 97(±3) | 33(±33) | 97(±3) | 33(±33) | 64(±22) | 0 |
Ethyl acetate | 100 | 67(±33) | 100 | 67(±33) | 100 | 63(±32) | 100 | 33(±33) | 67(±33) | 33(±33) | 67(±33) | 33(±33) |
Aqueous | 100 | 33(±33) | 100 | 33(±33) | 100 | 33(±33) | 79(±18) | 33(±33) | 78(±22) | 33(±33) | 59(±30) | 30(±30) |
Reference drugs | ||||||||||||
DMSPN | 49(±26) | 17(±17) | 25(±25) | 8(±8) | 3(±3) | 0 | 3(±3) | 0 | 3(±3) | 0 | 2(±2) | 0 |
Mel B | 22(±22) | 17(±17) | 22(22) | 0 | 6(±6) | 0 | 6(±6) | 0 | 0 | 0 | 0 | 0 |