Table 2 Percentage (± SE) of motile Onchocerca volvulus microfilariae found in 400 μg/ml and 800 μg/ml of Euphorbia hirta and Rauvolfia vomitoria extracts at 2 to 48 hrs
Extract/drug | Extract concentration(μg/ml) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
400 | 800 | 400 | 800 | 400 | 800 | 400 | 800 | 400 | 800 | 400 | 800 | |
2Â hrs | 4Â hrs | 6Â hrs | 12Â hrs | 24Â hrs | 48Â hrs | |||||||
Euphorbia hirta | ||||||||||||
Crude | 55(±24) | 27(±23) | 31(±26) | 12(±12) | 2(±2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hexane | 100 | 64(±32) | 87(±13) | 33(±33) | 87(±13) | 0 | 43(±20) | 0 | 4(±4) | 0 | 0 | 0 |
Chloroform | 50(±17) | 12(±9) | 17(±17) | 10(±1) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ethyl acetate | 24(±24) | 10(±10) | 2(±2) | 2(±2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aqueous | 46(±27) | 32(±21) | 28(±18) | 24(±24) | 2(±2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rauvolfia vomitoria | ||||||||||||
Crude | 88(±12) | 88(±12) | 48(±22) | 33(±27) | 42(±27) | 33(±33) | 30(±30) | 0 | 30(±30) | 0 | 22 (±22) | 0 |
Hexane | 98(±2) | 87(±13) | 96(±2) | 33(±33) | 96(±2) | 0 | 70(±18) | 0 | 21(±5) | 0 | 8 (±8) | 0 |
Chloroform | 80(±15) | 30(±10) | 76(±13) | 17(±17) | 59(±30) | 6(±6) | 56(±28) | 0 | 53(±27) | 0 | 0 | 0 |
Ethyl acetate | 100 | 12(±12) | 97(±3) | 0 | 97(±3) | 0 | 94(±3) | 0 | 60(±30) | 0 | 7(±7) | 0 |
Aqueous | 100 | 100 | 88(±9) | 67(±33) | 88(±9) | 42(±30) | 65(±32) | 23(±23) | 59(±30) | 23(±23) | 30 (±30) | 0 |
Reference drugs | ||||||||||||
DMSPN | 44(±28) | 15(±15) | 11(±9) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mel B | 88(±5) | 3(±3) | 65(±11) | 0 | 55(±2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |