Anti-inflammatory, gastroprotective and anti-ulcerogenic effects of red algae Gracilaria changii (Gracilariales, Rhodophyta) extract

Table 2 The effects of MeOHGCM6 extract pre-treatment on the rat’s gastric contents following EtOH-induced acute gastric mucosal injury

Pretreatment (n = 6)	Dose (mg/kg b.w.)	Mucus production (g)	Volume of gastric juice (ml)	Gastric pH
Diluent	-	2.45 ± 0.61	1.75 ± 0.50	7.40 ± 0.37
NSPE	500.0	2.75 ± 1.21	1.75 ± 0.69	4.35 ± 0.47*
OMP	20.0	2.31 ± 1.04	1.15 ± 0.88	6.97 ± 0.92
MeOHGCM6	2.5	2.33 ± 0.77	1.50 ± 0.61	5.51 ± 2.10
	5.0	3.24 ± 1.39	1.50 ± 0.61	5.42 ± 1.73
	250.0	1.54 ± 0.77	0.96 ± 0.62	4.74 ± 0.93*
	500.0	1.68 ± 0.47	0.96 ± 0.40	3.82 ± 0.58*

Rats were fed with the diluent, NSPE, OMP and the different MeOHGCM6 extract concentrations 30 minutes prior to feeding with absolute EtOH. Rats were sacrificed after an hour and gastric mucus secretion was collected and quantified. Results are expressed as mean ± S.D. from six animals.
* Significance difference in comparison to the group pre-treated with 10% Tween 20 (untreated control) value: p < 0.05.

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