Table 4 Comparison of anti-protozoal activity (IC 50 ) and cytotoxicity (CC 50 ) of alkaloids from Annickia kummeriae with standard drugs
Compound | IC50cpd IC50CQ | IC50cpd IC50Art | IC50cpd IC50Mel | IC50cpd IC50Milt | CC50cpd CC50Pdx |
|---|---|---|---|---|---|
Lysicamine (1) | 38.1 | 1,200.0 | 1,850.0 | 23.6 | 177.8 |
Trivalvone (2) | 25.4 | 800.0 | 7,150.0 | 26.4 | 5,033.3 |
Palmatine (3) | 1.3 | 40.0 | 1,600.0 | 70.9 | >10,000 |
Jatrorrhizine (4) | 3.8 | 120 | 2,100.0 | 185.5 | >10,000 |
Jatrorrhizine (4) + columbamine (5) (1.2:1.0) | 2.2 | 69.0 | 2,000.0 | 119.1 | 5,577.8 |
Palmatine (3) + (−)- tetrahydropalmatine (6) (1.1:1.0) | 1.6 | 49.0 | 2,150.0 | 63.64 | 6,855.6 |