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Table 5 Neurotransmitter levels and their metabolites (ng/g) after acute oral treatment with C . aurantium EO (5 mg/kg)

From: Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment

Structures and treatments

 

Cortex

Striatum

Pons

Hypothalamus

 

TW

EO

TW

EO

TW

EO

TW

EO

DA

845.6 ± 239.9 (10)

895.6 ± 321.3 (7)

8324.3 ± 517.1 (11)

8331.2 ± 1040.1 (7)

15.2 ± 3.8 (10)

18.6 ± 6.2 (7)

53.1 ± 3.8 (10)

58.3 ± 5.8 (6)

DOPAC

94.6 ± 15.9 (12)

85.6 ± 17.4 (8)

437.4 ± 44.5 (11)

415.5 ± 49.9 (7)

11.6 ± 1.6 (11)

8.4 ± 1.1 (8)

58.6 ± 5.6 (12)

64.2 ± 4.7 (8)

HVA

427.3 ± 80.4 (12)

567.8 ± 112.5 (8)

1121.9 ± 96.8 (11)

1384.9 ± 193.5 (7)

317.2 ± 87.9 (11)

388.3 ± 141.3 (8)

236.2 ± 36.8 (12)

388.8 ± 74.5 (8)

5HT

1246.9 ± 85.8 (12)

1270.1 ± 81.0 (8)

1686.3 ± 102.4 (11)

1665.9 ± 170.9 (7)

2782.4 ± 259.8 (11)

2075.4 ± 309.9 (8)

1660.1 ± 126.2 (12)

1599.2 ± 113.9 (8)

5HIAA

192.7 ± 17.5 (12)

229.3 ± 33.7 (8)

317.1 ± 30.9 (11)

320.3 ± 40.0 (7)

879.2 ± 69.5 (10)

644.1 ± 76.4 (7)

341.7 ± 20.9 (12)

310.9 ± 19.4 (8)

  1. TW (tween). The data are presented as the mean ± SEM. Any differences were compared with an unpaired t-test. The number of animals is different for each group because some structures could not be evaluated due to technical reasons.