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Table 4 Changes in body weight and biochemical parameters after 14 days of treatment with C . aurantium EO

From: Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment

Treatment

n

Body weight (g)

Biochemical parameters

  

Day 1

Day 14

UR (mg/dL)

CR (mg/dL)

TPRO (g/dL)

ALB (g/dL)

AST (UI/L)

AP (UI/L)

CHOL (mg/dL)

TRGL (mg/dL)

Tween

6

35 ± 4

43 ± 7

64.5 ± 10.1

0.3 ± 0.1

7.0 ± 0.1

3.9 ± 0.3

320.4 ± 85.5

164.8 ± 74.2

158.8 ± 35.2

173.8 ± 42.5

EO 1 mg/kg

7

34 ± 6

41 ± 10

64.4 ± 13.7

0.3 ± 0.2

7.9 ± 1.9

4.5 ± 0.9

334.2 ±5 2.7

131.4 ± 44.7

131.4 ± 27.2

143.6 ± 50.8

EO 5 mg/kg

6

34 ± 2

42 ± 4

65.3 ± 13.7

0.2 ± 0.1

6.9 ± 0.8

4.2 ± 0.9

377.4 ± 83.6

161.9 ± 64.0

135.2 ± 15.6

130.8 ± 37.5

EO 10 mg/kg

7

34 ± 4

40 ± 5

64.1 ± 11.9

0.2 ± 0.0

6.9 ± 0.6

3.9 ± 0.4

309.5 ± 45.2

123.3 ± 34.9

121.9 ± 20.4 *

132.7 ± 33.4

  1. The data are presented as the mean ± SD. UR (urea), CR (creatinine), TPRO (total protein), ALB (albumin), AST (aspartate aminotransferase), AP (alkaline phosphatase), CHOL (cholesterol), TRGL (triglycerides). * p ≤ 0.05 in relation to the control group (one-way ANOVA followed by the Dunnett’s Multiple Comparisons Test).