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Table 3 Effects of oral or inhaled C . aurantium EO on immobility time (s) in the forced swim test

From: Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment

Oral route

Inhalatory route

Treatment

n

Immobility (s)

Treatment

n

Immobility (s)

TW

5

226 (225–231)

SAL

5

207 (203–219)

IM

6

156 (120–165) *

IM

6

167 (164–171) *

EO 1 mg/kg

6

222 (215–238)

EO 0.5%

8

215 (207–221)

EO 5 mg/kg

7

234 (217–241)

EO 1.0%

8

194 (179–208)

EO 10 mg/kg

8

238(224–255)

EO 2.5%

8

220 (175–234)

EO 50 mg/kg

6

217 (206–222)

   
  1. The data are expressed as the median and interquartile range (Q1-Q3). TW: vehicle; SAL: isotonic saline solution; IM: imipramine hydrochloride, 30 mg/kg (i.p.); EO: C. aurantium essential oil. * p ≤ 0.05 in relation to the corresponding TW or SAL group (Kruskal-Wallis followed by Mann-Whitney U-Test).