TY - JOUR AU - Kambham, N. AU - Markowitz, G. S. AU - Valeri, A. M. AU - Lin, J. AU - D’Agati, V. D. PY - 2001 DA - 2001// TI - Obesity related glomerulopathy: an emerging epidemic JO - Kidney Int VL - 59 UR - https://doi.org/10.1046/j.1523-1755.2001.0590041498.x DO - 10.1046/j.1523-1755.2001.0590041498.x ID - Kambham2001 ER - TY - JOUR AU - Chen, J. AU - Muntner, P. AU - Hamm, L. L. AU - Jones, D. W. AU - Batuman, V. AU - Fonseca, V. AU - Whelton, P. K. AU - He, J. PY - 2004 DA - 2004// TI - The metabolic syndrome and chronic kidney disease in US adults JO - Ann Intern Med VL - 140 UR - https://doi.org/10.7326/0003-4819-140-3-200402030-00007 DO - 10.7326/0003-4819-140-3-200402030-00007 ID - Chen2004 ER - TY - JOUR AU - Pan, S. Y. AU - Desmeules, M. AU - Morrison, H. AU - Wen, S. W. PY - 2006 DA - 2006// TI - Obesity, high energy intake, lack of physical activity and the risk of kidney cancer JO - Cancer Epidemiol Biomarkers Prev VL - 15 UR - https://doi.org/10.1158/1055-9965.EPI-06-0616 DO - 10.1158/1055-9965.EPI-06-0616 ID - Pan2006 ER - TY - JOUR AU - Alberti, K. G. AU - Eckel, R. H. AU - Grundy, S. M. AU - Zimmet, P. Z. AU - Cleeman, J. I. AU - Donato, K. A. AU - Fruchart, J. C. AU - James, W. P. AU - Loria, C. M. AU - Smith, S. C. PY - 2009 DA - 2009// TI - Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity JO - Circulation VL - 120 UR - https://doi.org/10.1161/CIRCULATIONAHA.109.192644 DO - 10.1161/CIRCULATIONAHA.109.192644 ID - Alberti2009 ER - TY - JOUR AU - Mottillo, S. AU - Filion, K. B. AU - Genest, J. AU - Joseph, L. AU - Pilote, L. AU - Poirier, P. AU - Rinfret, S. AU - Schiffrin, E. L. AU - Eisenberg, M. J. PY - 2010 DA - 2010// TI - The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis JO - J Am Coll Cardiol VL - 56 UR - https://doi.org/10.1016/j.jacc.2010.05.034 DO - 10.1016/j.jacc.2010.05.034 ID - Mottillo2010 ER - TY - JOUR AU - Onat, A. PY - 2011 DA - 2011// TI - Metabolic syndrome: nature, therapeutic solutions and options JO - Expert Opin Pharmacother VL - 12 UR - https://doi.org/10.1517/14656566.2011.585462 DO - 10.1517/14656566.2011.585462 ID - Onat2011 ER - TY - JOUR AU - Jeong, Y. S. AU - Hong, J. H. AU - Cho, K. H. AU - Jung, H. K. PY - 2012 DA - 2012// TI - Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3 T3-L1 adipocytes through the peroxisome proliferator-activated receptor-γ signaling pathway JO - Nutr Res VL - 32 UR - https://doi.org/10.1016/j.nutres.2012.06.001 DO - 10.1016/j.nutres.2012.06.001 ID - Jeong2012 ER - TY - JOUR AU - Farmer, S. R. AU - Auwerx, J. PY - 2004 DA - 2004// TI - Adipose tissue: new therapeutic targets from molecular and genetic studies—IASO stock conference 2003 report JO - Obes Rev VL - 5 UR - https://doi.org/10.1111/j.1467-789X.2004.00157.x DO - 10.1111/j.1467-789X.2004.00157.x ID - Farmer2004 ER - TY - JOUR AU - Schaffer, J. E. PY - 2003 DA - 2003// TI - Lipotoxicity: when tissues overeat JO - Curr Opin Lipidol VL - 14 UR - https://doi.org/10.1097/00041433-200306000-00008 DO - 10.1097/00041433-200306000-00008 ID - Schaffer2003 ER - TY - JOUR AU - Unger, R. H. PY - 2002 DA - 2002// TI - Lipotoxic diseases JO - Annu Rev Med VL - 53 UR - https://doi.org/10.1146/annurev.med.53.082901.104057 DO - 10.1146/annurev.med.53.082901.104057 ID - Unger2002 ER - TY - JOUR AU - Unger, R. H. AU - Orci, L. PY - 2001 DA - 2001// TI - Diseases of liporegulation: new perspective on obesity and related disorders JO - FASEB J VL - 15 UR - https://doi.org/10.1096/fj.00-0590 DO - 10.1096/fj.00-0590 ID - Unger2001 ER - TY - JOUR AU - Weinberg, J. M. PY - 2006 DA - 2006// TI - Lipotoxicity JO - Kidney Int VL - 70 UR - https://doi.org/10.1038/sj.ki.5001834 DO - 10.1038/sj.ki.5001834 ID - Weinberg2006 ER - TY - JOUR AU - Vazquez-Vela, M. E. AU - Torres, N. AU - Tovar, A. R. PY - 2008 DA - 2008// TI - White adipose tissue as endocrine organ and its role in obesity JO - Arch Med Res VL - 39 UR - https://doi.org/10.1016/j.arcmed.2008.09.005 DO - 10.1016/j.arcmed.2008.09.005 ID - Vazquez-Vela2008 ER - TY - JOUR AU - Loftus, T. M. AU - Jaworsky, D. E. AU - Frehywot, G. L. AU - Townsend, C. A. AU - Ronnett, G. V. AU - Lane, M. D. AU - Kuhajda, F. P. PY - 2000 DA - 2000// TI - Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors JO - Science VL - 288 UR - https://doi.org/10.1126/science.288.5475.2379 DO - 10.1126/science.288.5475.2379 ID - Loftus2000 ER - TY - JOUR AU - Wakil, S. J. PY - 1989 DA - 1989// TI - Fatty acid synthase, a proficient multifunctional enzyme JO - Biochem VL - 28 UR - https://doi.org/10.1021/bi00437a001 DO - 10.1021/bi00437a001 ID - Wakil1989 ER - TY - JOUR AU - Smith, S. PY - 1994 DA - 1994// TI - The animal fatty acid synthase: one gene, one polypeptide, seven enzymes JO - FASEB J VL - 8 ID - Smith1994 ER - TY - JOUR AU - Guichard, C. AU - Dugail, I. AU - Leliepvre, X. AU - Lavau, M. PY - 1992 DA - 1992// TI - Genetic-regulation of fatty-acid synthetase expression in adipose tissue over transcription of the gene in genetically-obese rats JO - J Lipid Res VL - 33 ID - Guichard1992 ER - TY - JOUR AU - Rolland, V. AU - Dugail, I. AU - Leliepvre, X. AU - Lavau, M. PY - 1995 DA - 1995// TI - Evidence of increased glyceraldehyde-3-phosphate dehydrogenase and fatty-acid synthetase promoter activities in transiently transfected adipocytes from geneticallyobese rats JO - J Biol Chem VL - 270 UR - https://doi.org/10.1074/jbc.270.3.1102 DO - 10.1074/jbc.270.3.1102 ID - Rolland1995 ER - TY - JOUR AU - Berndt, J. AU - Kovacs, P. AU - Ruschke, K. AU - Kloting, N. AU - Fasshauer, M. AU - Schon, M. R. AU - Korner, A. AU - Stumvoll, M. AU - Bluher, M. PY - 2007 DA - 2007// TI - Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes JO - Diabetologia VL - 50 UR - https://doi.org/10.1007/s00125-007-0689-x DO - 10.1007/s00125-007-0689-x ID - Berndt2007 ER - TY - JOUR AU - Serrano, J. AU - Puupponen-Pimiä, R. AU - Dauer, A. AU - Aura, A. M. AU - Saura-Calixto, F. PY - 2009 DA - 2009// TI - Tannins: current knowledge of food sources, intake, bioavailability and biological effects JO - Mol Nutr Food Res VL - 53 UR - https://doi.org/10.1002/mnfr.200900039 DO - 10.1002/mnfr.200900039 ID - Serrano2009 ER - TY - JOUR AU - Bladé, C. AU - Arola, L. AU - Salvadó, M. J. PY - 2010 DA - 2010// TI - Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms JO - Mol Nutr Food Res VL - 54 UR - https://doi.org/10.1002/mnfr.200900476 DO - 10.1002/mnfr.200900476 ID - Bladé2010 ER - TY - JOUR AU - Nandakumar, V. AU - Singh, T. AU - Katiyar, S. K. PY - 2008 DA - 2008// TI - Multi-targeted prevention and therapy of cancer by proanthocyanidins JO - Cancer Lett VL - 269 UR - https://doi.org/10.1016/j.canlet.2008.03.049 DO - 10.1016/j.canlet.2008.03.049 ID - Nandakumar2008 ER - TY - JOUR AU - Ramirez-Tortosa, C. AU - Andersen, O. M. AU - Gardner, P. T. AU - Morrice, P. C. AU - Wood, S. G. AU - Duthie, S. J. AU - Collins, A. R. AU - Duthie, G. G. PY - 2001 DA - 2001// TI - Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin edepleted rats JO - Free Radic Biol Med VL - 31 UR - https://doi.org/10.1016/S0891-5849(01)00618-9 DO - 10.1016/S0891-5849(01)00618-9 ID - Ramirez-Tortosa2001 ER - TY - JOUR AU - Lee, S. J. AU - Choi, S. K. AU - Seo, J. S. PY - 2009 DA - 2009// TI - Grape skin improves antioxidant capacity in rats fed a high fat diet JO - Nutr Res Pract VL - 3 UR - https://doi.org/10.4162/nrp.2009.3.4.279 DO - 10.4162/nrp.2009.3.4.279 ID - Lee2009 ER - TY - JOUR AU - Jeong, Y. S. AU - Jung, H. K. AU - Cho, K. H. AU - Hong, J. H. PY - 2011 DA - 2011// TI - Anti-obesity effect of grape skin extract in 3 T3-L1 adipocytes JO - Food Sci Biotechnol VL - 20 UR - https://doi.org/10.1007/s10068-011-0090-x DO - 10.1007/s10068-011-0090-x ID - Jeong2011 ER - TY - JOUR AU - Stervbo, U. AU - Vang, O. AU - Bonnesen, C. PY - 2007 DA - 2007// TI - A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine JO - Food Chem VL - 101 UR - https://doi.org/10.1016/j.foodchem.2006.01.047 DO - 10.1016/j.foodchem.2006.01.047 ID - Stervbo2007 ER - TY - JOUR AU - Baur, J. A. AU - Pearson, K. J. AU - Price, N. L. AU - Jamieson, H. A. AU - Lerin, C. AU - Kalra, A. AU - Prabhu, V. V. AU - Allard, J. S. AU - Lopez-Lluch, G. AU - Lewis, K. AU - Pistell, P. J. AU - Poosala, S. AU - Becker, K. G. AU - Boss, O. AU - Gwinn, D. AU - Wang, M. AU - Ramaswamy, S. AU - Fishbein, K. W. AU - Spencer, R. G. AU - Lakatta, E. G. AU - Le Couteur, D. AU - Shaw, R. J. AU - Navas, P. AU - Puigserver, P. AU - Ingram, D. K. AU - De Cabo, R. AU - Sinclair, D. A. PY - 2006 DA - 2006// TI - Resveratrol improves health and survival of mice on a high-calorie diet JO - Nature VL - 444 UR - https://doi.org/10.1038/nature05354 DO - 10.1038/nature05354 ID - Baur2006 ER - TY - JOUR AU - Lagouge, M. AU - Argmann, C. AU - Gerhart-Hines, Z. AU - Meziane, H. AU - Lerin, C. AU - Daussin, F. AU - Messadeq, N. AU - Milne, J. AU - Lambert, P. AU - Elliott, P. AU - Geny, B. AU - Laakso, M. AU - Puigserve, P. AU - Auwerx, J. PY - 2006 DA - 2006// TI - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha JO - Cell VL - 127 UR - https://doi.org/10.1016/j.cell.2006.11.013 DO - 10.1016/j.cell.2006.11.013 ID - Lagouge2006 ER - TY - JOUR AU - Timmers, S. AU - Konings, E. AU - Bilet, L. AU - Houtkooper, R. H. AU - Van de Weijer, T. AU - Goossens, G. H. AU - Hoeks, J. AU - Van der Krieken, S. AU - Ryu, D. AU - Kersten, S. AU - Moonen-Kornips, E. AU - Hesselink, M. K. C. AU - Kunz, I. AU - Schrauwen-Hinderling, V. B. AU - Blaak, E. E. AU - Auwerx, J. AU - Schrauwen, P. PY - 2011 DA - 2011// TI - Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans JO - Cell Metab VL - 14 UR - https://doi.org/10.1016/j.cmet.2011.10.002 DO - 10.1016/j.cmet.2011.10.002 ID - Timmers2011 ER - TY - JOUR AU - Jayakumar, A. AU - Tai, M. H. AU - Huang, W. Y. AU - Al-Feel, W. AU - Hsu, M. AU - Abu-Elheiga, L. AU - Chirala, S. S. AU - Wakil, S. J. PY - 1995 DA - 1995// TI - Human fatty acid synthase: properties and molecular cloning JO - Proc Natl Acad Sci USA VL - 92 UR - https://doi.org/10.1073/pnas.92.19.8695 DO - 10.1073/pnas.92.19.8695 ID - Jayakumar1995 ER - TY - JOUR AU - Tian, W. X. AU - Hsu, R. Y. AU - Wang, Y. S. PY - 1985 DA - 1985// TI - Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty acid synthetase of chicken liver: inactivation by 5, 5′-dithiobis-(2-nitrobenzoic acid) and intersubunit cross-linking of the inactivated enzyme JO - J Biol Chem VL - 260 ID - Tian1985 ER - TY - JOUR AU - Sun, Y. H. AU - Cheng, Q. AU - Tian, W. X. AU - Wu, X. D. PY - 2008 DA - 2008// TI - A substitutive substrate for measurements of beta-ketoacyl reductases in two fatty acid synthase systems JO - J Biochem Biophys Methods VL - 70 UR - https://doi.org/10.1016/j.jbbm.2007.10.005 DO - 10.1016/j.jbbm.2007.10.005 ID - Sun2008 ER - TY - JOUR AU - Wang, X. AU - Tian, W. X. PY - 2001 DA - 2001// TI - Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase JO - Biochem Biophys Res Commun VL - 288 UR - https://doi.org/10.1006/bbrc.2001.5923 DO - 10.1006/bbrc.2001.5923 ID - Wang2001 ER - TY - JOUR AU - Wang, X. AU - Song, K. H. AU - Guo, Q. X. AU - Tian, W. X. PY - 2003 DA - 2003// TI - The galloyl moiety of green tea catechins is critical structural feature to inhibit fatty-acid synthase JO - Biochem Pharmacol VL - 66 UR - https://doi.org/10.1016/S0006-2952(03)00585-9 DO - 10.1016/S0006-2952(03)00585-9 ID - Wang2003 ER - TY - JOUR AU - Kuhajda, F. P. AU - Pizer, E. S. AU - Li, J. N. AU - Mani, N. S. AU - Frehywot, G. L. AU - Townsend, C. A. PY - 2000 DA - 2000// TI - Synthesis and antitumor activity of an inhibitor of fatty acid synthase JO - Proc Natl Acad Sci USA VL - 97 UR - https://doi.org/10.1073/pnas.97.7.3450 DO - 10.1073/pnas.97.7.3450 ID - Kuhajda2000 ER - TY - JOUR AU - Zhang, R. AU - Xiao, W. AU - Wang, X. AU - Wu, X. AU - Tian, W. PY - 2006 DA - 2006// TI - Novel inhibitors of fatty-acid synthase from green tea (Camellia sinensis Xihu Longjing) with high activity and a new reacting site JO - Biotechnol Appl Biochem VL - 43 UR - https://doi.org/10.1042/BA20050135 DO - 10.1042/BA20050135 ID - Zhang2006 ER - TY - JOUR AU - Li, B. H. AU - Ma, X. F. AU - Wang, Y. AU - Tian, W. X. PY - 2005 DA - 2005// TI - Structure-activity relationship of polyphenols that inhibit fatty acid synthase JO - J Biochem (Tokyo) VL - 138 UR - https://doi.org/10.1093/jb/mvi171 DO - 10.1093/jb/mvi171 ID - Li2005 ER - TY - JOUR AU - Watson, W. H. AU - Cai, J. AU - Jones, D. P. PY - 2000 DA - 2000// TI - Diet and apoptosis JO - Annu Rev Nutr VL - 20 UR - https://doi.org/10.1146/annurev.nutr.20.1.485 DO - 10.1146/annurev.nutr.20.1.485 ID - Watson2000 ER - TY - JOUR AU - Matito, C. AU - Mastorakou, F. AU - Centelles, J. J. AU - Torres, J. L. AU - Cascante, M. PY - 2003 DA - 2003// TI - Antiproliferative effect of antioxidant polyphenols from grape in murine Hepa-1c1c7 JO - Eur J Nutr VL - 42 UR - https://doi.org/10.1007/s00394-003-0398-2 DO - 10.1007/s00394-003-0398-2 ID - Matito2003 ER - TY - JOUR AU - Formica, J. V. AU - Regelson, W. PY - 1995 DA - 1995// TI - Review of the biology of Quercetin and related bioflavonoids JO - Food Chem Toxicol VL - 33 UR - https://doi.org/10.1016/0278-6915(95)00077-1 DO - 10.1016/0278-6915(95)00077-1 ID - Formica1995 ER - TY - JOUR AU - Plaumann, B. AU - Fritsche, M. AU - Rimpler, H. AU - Brandner, G. AU - Hess, R. D. PY - 1996 DA - 1996// TI - Flavonoids activate wild-type p53 JO - Oncogene VL - 13 ID - Plaumann1996 ER - TY - JOUR AU - Caltagirone, S. AU - Rossi, C. AU - Poggi, A. AU - Ranelletti, F. O. AU - Natali, P. G. AU - Brunetti, M. AU - Aiello, F. B. AU - Piantelli, M. PY - 2000 DA - 2000// TI - Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential JO - Int J Cancer VL - 87 UR - https://doi.org/3.0.CO;2-5 DO - 3.0.CO;2-5 ID - Caltagirone2000 ER - TY - JOUR AU - Schmid, B. AU - Rippmann, J. F. AU - Tadayyon, M. AU - Hamilton, B. S. PY - 2005 DA - 2005// TI - Inhibition of fatty acid synthase prevents preadipocyte differentiation JO - Biochem Biophys Res Commun VL - 328 UR - https://doi.org/10.1016/j.bbrc.2005.01.067 DO - 10.1016/j.bbrc.2005.01.067 ID - Schmid2005 ER - TY - JOUR AU - Clarde, W. L. AU - Armstrong, M. K. AU - Jump, D. B. PY - 1990 DA - 1990// TI - Nutritional control of rat liver fatty acid synthase and S14 mRNA abundance JO - J Nutr VL - 120 ID - Clarde1990 ER - TY - JOUR AU - Mobbs, C. V. AU - Makimura, H. PY - 2002 DA - 2002// TI - Block the FAS, lose the fat JO - Nutr Med VL - 8 ID - Mobbs2002 ER - TY - JOUR AU - Moon, H. S. AU - Chung, C. S. AU - Lee, H. G. AU - Kim, T. G. AU - Choi, Y. J. AU - Cho, C. S. PY - 2007 DA - 2007// TI - Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation of 3 T3-L1 cells JO - Obesity VL - 15 UR - https://doi.org/10.1038/oby.2007.309 DO - 10.1038/oby.2007.309 ID - Moon2007 ER - TY - JOUR AU - Thupari, J. N. AU - Pinn, M. L. AU - Kuhajda, F. P. PY - 2001 DA - 2001// TI - Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity JO - Biochem Biophys Res Commun VL - 285 UR - https://doi.org/10.1006/bbrc.2001.5146 DO - 10.1006/bbrc.2001.5146 ID - Thupari2001 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/13/361/prepub UR - http://www.biomedcentral.com/1472-6882/13/361/prepub ID - ref48 ER -